Reaction Details Report a problem with these data
Target
NAD-dependent protein deacetylase sirtuin-2
Ligand
BDBM50309833
Substrate
n/a
Meas. Tech.
ChEMBL_611474 (CHEMBL1069456)
IC50
>10000±n/a nM
Citation
 Pasco, MY; Rotili, D; Altucci, L; Farina, F; Rouleau, GA; Mai, A; Néri, C Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues. J Med Chem 53:1407-11 (2010) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-2
Synonyms:
NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2)
Type:
Hydrolase
Mol. Mass.:
43172.62
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
389
Sequence:
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
  
Inhibitor
Name:
BDBM50309833
Synonyms:
(S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CHEMBL597477
Type:
Small organic molecule
Emp. Form.:
C13H13ClN2O
Mol. Mass.:
248.708
SMILES:
NC(=O)[C@H]1CCCc2c1[nH]c1ccc(Cl)cc21 |r|
Structure:
Search PDB for entries with ligand similarity: