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Target
Protein arginine N-methyltransferase 1 [11-371]
Ligand
BDBM50311688
Substrate
n/a
Meas. Tech.
ChEMBL_618696 (CHEMBL1102474)
IC50
>100000±n/a nM
Citation
 Therrien, E; Larouche, G; Manku, S; Allan, M; Nguyen, N; Styhler, S; Robert, MF; Goulet, AC; Besterman, JM; Nguyen, H; Wahhab, A 1,2-Diamines as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1). Bioorg Med Chem Lett 19:6725-32 (2009) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 1 [11-371]
Synonyms:
ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1
Type:
Protein
Mol. Mass.:
41506.52
Organism:
Homo sapiens (Human)
Description:
Q99873[11-371]
Residue:
361
Sequence:
MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM50311688
Synonyms:
CHEMBL1080460 | N-(2-methoxybenzyl)-1-(3-((2-(methylamino)ethylamino)methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
Type:
Small organic molecule
Emp. Form.:
C23H26F3N5O2
Mol. Mass.:
461.48
SMILES:
CNCCNCc1cccc(c1)-n1nc(cc1C(=O)NCc1ccccc1OC)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: