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Found 202 with Last Name = 'manku' and Initial = 's'
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50277188(CHEMBL473270 | N1-(biphenyl-3-yl)-N8-hydroxyoctane...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant N-terminal histidine-tagged HDAC6 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50277188(CHEMBL473270 | N1-(biphenyl-3-yl)-N8-hydroxyoctane...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant C-terminal FLAG-tagged HDAC1 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255852(4-(((R)-3-(4-hydroxybenzyl)-2,3-dihydro-2-oxoquino...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255096(4-(((R)-3-benzyl-2,3-dihydro-2-oxoquinoxalin-4(1H)...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant histone deacetylase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255853(4-(((R)-2,3-dihydro-2-oxo-3-phenethylquinoxalin-4(...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255914(4-(((R)-2,3-dihydro-2-oxo-3-((thiophen-2-yl)methyl...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255809(4-(((R)-3-(3,4-difluorobenzyl)-2,3-dihydro-2-oxoqu...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255854((R)-tert-butyl 4-(1-(4-(hydroxycarbamoyl)benzyl)-3...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255910(4-(((R)-3-(4-tert-butoxybenzyl)-2,3-dihydro-2-oxoq...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50277329((S)-benzyl 1-(6-methoxyquinolin-8-ylamino)-1-oxo-6...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant N-terminal histidine-tagged HDAC6 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Mus musculus (mouse))
Methylgene

Curated by ChEMBL
LigandPNGBDBM27641(1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-[(...)
Affinity DataIC50:  60nMAssay Description:Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Mus musculus (mouse))
Methylgene

Curated by ChEMBL
LigandPNGBDBM27641(1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-[(...)
Affinity DataIC50:  60nMpH: 9.0 T: 2°CAssay Description:Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Mus musculus (mouse))
Methylgene

Curated by ChEMBL
LigandPNGBDBM27642(1-(5-{[(2S)-2-aminopropanamido]methyl}thiophen-3-y...)
Affinity DataIC50:  60nMpH: 9.0 T: 2°CAssay Description:Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50257130((S)-2-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetami...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human recombinant FLAG-tagged HDAC1 expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Mus musculus (mouse))
Methylgene

Curated by ChEMBL
LigandPNGBDBM27659(1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-be...)
Affinity DataIC50:  80nMpH: 9.0 T: 2°CAssay Description:Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50257173((S)-benzyl 1-(1H-benzo[d]imidazol-2-yl)-5-(sulfamo...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant His-tagged HDAC6 expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant C-terminal FLAG-tagged HDAC1 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255912(4-(((R)-2-((1H-indol-3-yl)methyl)-3,6-dioxopiperaz...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50256996((S)-benzyl 1-(4-(4-methoxyphenyl)thiazol-2-ylamino...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human recombinant FLAG-tagged HDAC1 expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50257091((S)-2-(2-phenylacetamido)-N-(4-phenylthiazol-2-yl)...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human recombinant His-tagged HDAC6 expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255097(4-((2,3-dihydro-2-oxoquinoxalin-4(1H)-yl)methyl)-N...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50257046((S)-benzyl 1-(4-(4-chlorophenyl)thiazol-2-ylamino)...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human recombinant FLAG-tagged HDAC1 expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50256888((S)-benzyl 1-oxo-1-(4-phenylthiazol-2-ylamino)-6-(...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant FLAG-tagged HDAC1 expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255913(CHEMBL481726 | N-hydroxy-4-(((R)-3,6-dioxo-2-((thi...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50256888((S)-benzyl 1-oxo-1-(4-phenylthiazol-2-ylamino)-6-(...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant C-terminal FLAG-tagged HDAC1 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255911(4-(((R)-2-benzyl-3,6-dioxopiperazin-1-yl)methyl)-N...)
Affinity DataIC50:  170nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50256888((S)-benzyl 1-oxo-1-(4-phenylthiazol-2-ylamino)-6-(...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human recombinant N-terminal histidine-tagged HDAC6 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50256888((S)-benzyl 1-oxo-1-(4-phenylthiazol-2-ylamino)-6-(...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human recombinant His-tagged HDAC6 expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50256945((S)-benzyl 1-(benzo[d]thiazol-2-ylamino)-1-oxo-6-(...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human recombinant His-tagged HDAC6 expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant N-terminal histidine-tagged HDAC6 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone-arginine methyltransferase CARM1(Mus musculus (mouse))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50311688(CHEMBL1080460 | N-(2-methoxybenzyl)-1-(3-((2-(meth...)
Affinity DataIC50:  200nMAssay Description:Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50256996((S)-benzyl 1-(4-(4-methoxyphenyl)thiazol-2-ylamino...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant His-tagged HDAC6 expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50256887((S)-ethyl 1-oxo-1-(4-phenylthiazol-2-ylamino)-6-(s...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant His-tagged HDAC6 expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50257223((S)-benzyl 5-(sulfamoylamino)-1-(5-(thiophen-2-yl)...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant FLAG-tagged HDAC1 expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255095(4-(((S)-3-benzyl-2,3-dihydro-2-oxoquinoxalin-4(1H)...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human recombinant histone deacetylase 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255095(4-(((S)-3-benzyl-2,3-dihydro-2-oxoquinoxalin-4(1H)...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Mus musculus (mouse))
Methylgene

Curated by ChEMBL
LigandPNGBDBM27650(1-(5-{[(2S)-2-aminopropanamido]methyl}thiophen-3-y...)
Affinity DataIC50:  220nMpH: 9.0 T: 2°CAssay Description:Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Mus musculus (mouse))
Methylgene

Curated by ChEMBL
LigandPNGBDBM27655(1-(5-{[(2S)-2-aminopropanamido]methyl}thiophen-2-y...)
Affinity DataIC50:  230nMpH: 9.0 T: 2°CAssay Description:Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50257046((S)-benzyl 1-(4-(4-chlorophenyl)thiazol-2-ylamino)...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human recombinant His-tagged HDAC6 expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255910(4-(((R)-3-(4-tert-butoxybenzyl)-2,3-dihydro-2-oxoq...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human recombinant histone deacetylase 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255096(4-(((R)-3-benzyl-2,3-dihydro-2-oxoquinoxalin-4(1H)...)
Affinity DataIC50:  260nMAssay Description:Inhibition of human recombinant histone deacetylase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Mus musculus (mouse))
Methylgene

Curated by ChEMBL
LigandPNGBDBM27651(1-(5-{[(2S)-2-aminopropanamido]methyl}thiophen-3-y...)
Affinity DataIC50:  260nMpH: 9.0 T: 2°CAssay Description:Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50256947((S)-3-chlorobenzyl 1-oxo-1-(4-phenylthiazol-2-ylam...)
Affinity DataIC50:  280nMAssay Description:Inhibition of human recombinant His-tagged HDAC6 expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50257224((S)-benzyl 1-(2-phenyl-1H-imidazol-4-yl)-5-(sulfam...)
Affinity DataIC50:  290nMAssay Description:Inhibition of human recombinant FLAG-tagged HDAC1 expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Mus musculus (mouse))
Methylgene

Curated by ChEMBL
LigandPNGBDBM27643(1-(5-{[(2S)-2-aminopropanamido]methyl}thiophen-2-y...)
Affinity DataIC50:  300nMpH: 9.0 T: 2°CAssay Description:Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255851(4-(((S)-2,3-dihydro-2-oxo-3-((thiophen-2-yl)methyl...)
Affinity DataIC50:  310nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50257225((S)-benzyl 1-(5-phenyl-1H-1,2,4-triazol-3-yl)-5-(s...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human recombinant His-tagged HDAC6 expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Mus musculus (mouse))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50311707(1-(3-((2-(methylamino)ethylamino)methyl)phenyl)-N-...)
Affinity DataIC50:  320nMAssay Description:Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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