Reaction Details
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IgG receptor FcRn large subunit p51
Ligand
BDBM50314104
Substrate
n/a
Meas. Tech.
ChEMBL_627629 (CHEMBL1114459)
IC50
20±n/a nM
Citation
McDonnell, KA; Low, SC; Hoehn, T; Donnelly, R; Palmieri, H; Fraley, C; Sakorafas, P; Mezo, AR Synthesis and structure-activity relationships of dimeric peptide antagonists of the human immunoglobulin G-human neonatal Fc receptor (IgG-FcRn) interaction. J Med Chem 53:1587-96 (2010) [PubMed] Article More Info.:
Target
Name:
IgG receptor FcRn large subunit p51
Synonyms:
FCGRN_HUMAN | FCGRT | FCRN
Type:
PROTEIN
Mol. Mass.:
39742.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_627631
Residue:
365
Sequence:
MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA
Inhibitor
Name:
BDBM50314104
Synonyms:
CHEMBL1090969 | N1,N4-bis((S)-1-((S)-1-((3R,8R,11S,17S,26S,29S,35aS)-3-carbamoyl-17-(4-guanidinobenzyl)-29-(4-hydroxybenzyl)-11-((R)-1-hydroxyethyl)-26-isobutyl-7,7,22,25-tetramethyl-1,9,12,15,18,21,24,27,30,31-decaoxodotriacontahydro-1H-pyrrolo[2,1-g][1,2,5,8,12,15,18,21,24,27,30]dithianonaazacyclotritriacontin-8-ylamino)-1-oxo-3-phenylpropan-2-ylamino)-5-guanidino-1-oxopentan-2-yl)succinamide
Type:
Small organic molecule
Emp. Form.:
C136H192N38O32S4
Mol. Mass.:
2999.475
SMILES:
[#6]-[#6](-[#6])-[#6]-[#6@@H]-1-[#7](-[#6])-[#6](=O)-[#6]-[#7](-[#6])-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-c2ccc(cc2)\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c2ccccc2)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#7]-[#6](-[#7])=[#7])-[#7]-[#6](=O)-[#6]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#7]-[#6](-[#7])=[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c2ccccc2)-[#6](=O)-[#7]-[#6@@H]2-[#6](=O)-[#7]-[#6@@H](-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c3ccc(cc3)\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7](-[#6])-[#6]-[#6](=O)-[#7](-[#6])-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-c3ccc(-[#8])cc3)-[#6](=O)-[#6](=O)-[#7]-3-[#6]-[#6]-[#6]-[#6@H]-3-[#6](=O)-[#7]-[#6@@H](-[#6]-[#16]-[#16]C2([#6])[#6])-[#6](-[#7])=O)C([#6])([#6])[#16]-[#16]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H]-2-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6](=O)-[#6@H](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6]-1=O)-[#6](-[#7])=O)-[#6@@H](-[#6])-[#8] |r|
Structure:
