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Target
Death-associated protein kinase 3
Ligand
BDBM50314673
Substrate
n/a
Meas. Tech.
ChEMBL_625624 (CHEMBL1112575)
IC50
157±n/a nM
Citation
 Okamoto, M; Takayama, K; Shimizu, T; Muroya, A; Furuya, T Structure-activity relationship of novel DAPK inhibitors identified by structure-based virtual screening. Bioorg Med Chem 18:2728-34 (2010) [PubMed]  Article 
Target
Name:
Death-associated protein kinase 3
Synonyms:
DAP kinase 3 | DAP-like kinase | DAPK3 | DAPK3_HUMAN | ZIP-kinase | ZIPK
Type:
PROTEIN
Mol. Mass.:
52537.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586564
Residue:
454
Sequence:
MSTFRQEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGEDSGRKPERRRLKTTRLKEYTIKSHSSLPPNNSYADFERFSKVLEEAAAAEEGLRELQRSRRLCHEDVEALAAIYEEKEAWYREESDSLGQDLRRLRQELLKTEALKRQAQEEAKGALLGTSGLKRRFSRLENRYEALAKQVASEMRFVQDLVRALEQEKLQGVECGLR
  
Inhibitor
Name:
BDBM50314673
Synonyms:
2-(2-bromo-4-methoxyphenyl)-4-(pyridin-3-ylmethylene)oxazol-5(4H)-one | CHEMBL1091042
Type:
Small organic molecule
Emp. Form.:
C16H11BrN2O3
Mol. Mass.:
359.174
SMILES:
COc1ccc(C2=N\C(=C/c3cccnc3)C(=O)O2)c(Br)c1 |t:6|
Structure:
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