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Target
Melanocortin receptor 4
Ligand
BDBM50314764
Substrate
n/a
Meas. Tech.
ChEMBL_626193 (CHEMBL1107127)
EC50
22±n/a nM
Citation
 He, S; Ye, Z; Dobbelaar, PH; Sebhat, IK; Guo, L; Liu, J; Jian, T; Lai, Y; Franklin, CL; Bakshi, RK; Dellureficio, JP; Hong, Q; Tsou, NN; Ball, RG; Cashen, DE; Martin, WJ; Weinberg, DH; Macneil, T; Tang, R; Tamvakopoulos, C; Peng, Q; Miller, RR; Stearns, RA; Chen, HY; Chen, AS; Strack, AM; Fong, TM; Macintyre, DE; Wyvratt, MJ; Nargund, RP Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist. Bioorg Med Chem Lett 20:2106-10 (2010) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R_MOUSE | Mc4r
Type:
PROTEIN
Mol. Mass.:
36964.43
Organism:
Mus musculus
Description:
ChEMBL_1498850
Residue:
332
Sequence:
MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY
  
Inhibitor
Name:
BDBM50314764
Synonyms:
CHEMBL1093304 | trans-N-(2-((R)-1'-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)propan-2-yl)acetamide
Type:
Small organic molecule
Emp. Form.:
C34H44ClF2N3O2
Mol. Mass.:
600.182
SMILES:
CC(=O)NC(C)(C)[C@@H]1CC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C(C)(C)C)c2cc(Cl)c(C)cc12 |r|
Structure:
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