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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50314783
Substrate
n/a
Meas. Tech.
ChEMBL_627007 (CHEMBL1103663)
Ki
8±n/a nM
Citation
 Pettus, LH; Wurz, RP; Xu, S; Herberich, B; Henkle, B; Liu, Q; McBride, HJ; Mu, S; Plant, MH; Saris, CJ; Sherman, L; Wong, LM; Chmait, S; Lee, MR; Mohr, C; Hsieh, F; Tasker, AS Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase. J Med Chem 53:2973-85 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50314783
Synonyms:
CHEMBL1091927 | N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-3,7-dimethyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-5-yl)-4-methylbenzamide
Type:
Small organic molecule
Emp. Form.:
C25H22F2N4O2
Mol. Mass.:
448.4646
SMILES:
Cc1nn(-c2c(F)cccc2F)c2n(C)c(=O)c(cc12)-c1cc(ccc1C)C(=O)NC1CC1 |(5.79,-3.45,;5.32,-1.98,;6.23,-.74,;5.31,.53,;6.08,1.86,;7.58,1.93,;8.35,.57,;8.35,3.26,;7.52,4.55,;5.98,4.56,;5.31,3.21,;3.73,3.4,;3.86,.04,;2.53,.82,;2.54,2.36,;1.2,.06,;-.13,.84,;1.19,-1.48,;2.52,-2.26,;3.86,-1.5,;-.15,-2.24,;-1.48,-1.47,;-2.82,-2.23,;-2.83,-3.77,;-1.5,-4.55,;-.16,-3.78,;1.17,-4.56,;-4.15,-1.45,;-4.14,.09,;-5.48,-2.22,;-6.81,-1.44,;-8.35,-1.43,;-7.58,-.1,)|
Structure:
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