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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50314792
Substrate
n/a
Meas. Tech.
ChEMBL_627007 (CHEMBL1103663)
Ki
2±n/a nM
Citation
 Pettus, LH; Wurz, RP; Xu, S; Herberich, B; Henkle, B; Liu, Q; McBride, HJ; Mu, S; Plant, MH; Saris, CJ; Sherman, L; Wong, LM; Chmait, S; Lee, MR; Mohr, C; Hsieh, F; Tasker, AS Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase. J Med Chem 53:2973-85 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50314792
Synonyms:
1-(2,6-Difluorophenyl)-7-methyl-5-(6-methyl-3-(methylamino)-benzo[d]isoxazol-7-yl)-1H-pyrazolo[3,4-b]pyridin-6(7H)-one | CHEMBL1089513
Type:
Small organic molecule
Emp. Form.:
C22H17F2N5O2
Mol. Mass.:
421.3995
SMILES:
CNc1noc2c(c(C)ccc12)-c1cc2cnn(-c3c(F)cccc3F)c2n(C)c1=O |(-7.45,-.18,;-6.45,-1.35,;-4.93,-1.06,;-4.28,.33,;-2.75,.13,;-2.46,-1.38,;-1.15,-2.18,;-1.18,-3.72,;.13,-4.52,;-2.53,-4.46,;-3.85,-3.66,;-3.81,-2.12,;.2,-1.44,;1.52,-2.24,;2.87,-1.5,;4.32,-2.01,;5.26,-.78,;4.36,.5,;5.16,1.81,;6.65,1.86,;7.4,.49,;7.45,3.17,;6.64,4.48,;5.1,4.52,;4.41,3.18,;2.83,3.4,;2.91,.04,;1.59,.84,;1.62,2.38,;.24,.1,;-1.08,.9,)|
Structure:
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