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Target
Ribosyldihydronicotinamide dehydrogenase [quinone]
Ligand
BDBM50317139
Substrate
n/a
Meas. Tech.
ChEMBL_630842 (CHEMBL1109212)
IC50
31±n/a nM
Citation
 Nolan, KA; Humphries, MP; Bryce, RA; Stratford, IJ Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett 20:2832-6 (2010) [PubMed]  Article 
Target
Name:
Ribosyldihydronicotinamide dehydrogenase [quinone]
Synonyms:
Metallothionein-3 | NMOR2 | NQO2 | NQO2_HUMAN | NRH dehydrogenase [quinone] 2 | NRH:quinone oxidoreductase 2 | QR2 | Quinone reductase 2 | Quinone reductase 2 (NQO2) | Ribosyldihydronicotinamide dehydrogenase [quinone]
Type:
Protein
Mol. Mass.:
25917.25
Organism:
Homo sapiens (Human)
Description:
P16083
Residue:
231
Sequence:
MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ
  
Inhibitor
Name:
BDBM50317139
Synonyms:
5-(2-(diethylamino)ethylamino)-7-hydroxy-10-methoxy-6H-imidazo[4,5,1-de]acridin-6-one | 5-(2-Diethylamino-ethylamino)-7-hydroxy-10-methoxy-2,10b-diaza-aceanthrylen-6-one | CHEMBL8219 | NSC-660840
Type:
Small organic molecule
Emp. Form.:
C21H24N4O3
Mol. Mass.:
380.4403
SMILES:
CCN(CC)CCNc1ccc2ncn3c2c1c(=O)c1c(O)ccc(OC)c31
Structure:
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