Reaction Details Report a problem with these data
Target
P2Y purinoceptor 12
Ligand
BDBM50318031
Substrate
n/a
Meas. Tech.
ChEMBL_631130 (CHEMBL1107394)
IC50
0.7±n/a nM
Citation
 Calleri, E; Ceruti, S; Cristalli, G; Martini, C; Temporini, C; Parravicini, C; Volpini, R; Daniele, S; Caccialanza, G; Lecca, D; Lambertucci, C; Trincavelli, ML; Marucci, G; Wainer, IW; Ranghino, G; Fantucci, P; Abbracchio, MP; Massolini, G Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor. J Med Chem 53:3489-501 (2010) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 12
Synonyms:
ADP-glucose receptor | ADPG-R | HORK3 | P2RY12 | P2T(AC) | P2Y purinoceptor 12 | P2Y(AC) | P2Y(ADP) | P2Y(cyc) | P2Y12 | P2Y12 platelet ADP receptor | P2Y12_HUMAN | Purinergic receptor P2Y12 | SP1999
Type:
Enzyme
Mol. Mass.:
39458.48
Organism:
Homo sapiens (Human)
Description:
Q9H244
Residue:
342
Sequence:
MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
  
Inhibitor
Name:
BDBM50318031
Synonyms:
CHEMBL1097279 | cangrelor
Type:
Small organic molecule
Emp. Form.:
C17H21Cl2F3N5O12P3S2
Mol. Mass.:
772.33
SMILES:
CSCCNc1nc(SCCC(F)(F)F)nc2n(cnc12)[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)C(Cl)(Cl)P([O-])([O-])=O)[C@@H](O)[C@H]1O |r|
Structure:
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