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Target
Adenosine receptor A2a
Ligand
BDBM57851
Substrate
n/a
Meas. Tech.
ChEMBL_629286 (CHEMBL1117497)
Ki
400±n/a nM
Citation
 Carlsson, J; Yoo, L; Gao, ZG; Irwin, JJ; Shoichet, BK; Jacobson, KA Structure-based discovery of A2A adenosine receptor ligands. J Med Chem 53:3748-55 (2010) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM57851
Synonyms:
1-(4,6-dimethyl-2-pyrimidinyl)-2-[2-(1H-indol-3-yl)ethyl]guanidine | 1-(4,6-dimethylpyrimidin-2-yl)-2-[2-(1H-indol-3-yl)ethyl]guanidine | CHEMBL1097074 | MLS000710227 | SMR000287394 | cid_2947810
Type:
Small organic molecule
Emp. Form.:
C17H20N6
Mol. Mass.:
308.3809
SMILES:
Cc1cc(C)nc(NC(N)=NCCc2c[nH]c3ccccc23)n1 |w:10.10|
Structure:
Search PDB for entries with ligand similarity: