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Target
Large neutral amino acids transporter small subunit 1
Ligand
BDBM50319696
Substrate
n/a
Meas. Tech.
ChEMBL_634759 (CHEMBL1119375)
Ki
2100±n/a nM
Citation
 Matharu, J; Oki, J; Worthen, DR; Smith, QR; Crooks, PA Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier. Bioorg Med Chem Lett 20:3688-91 (2010) [PubMed]  Article 
Target
Name:
Large neutral amino acids transporter small subunit 1
Synonyms:
L-type amino acid transporter 1 | LAT1_RAT | Lat1 | Mpe16 | Slc7a5 | Ta1
Type:
PROTEIN
Mol. Mass.:
55907.74
Organism:
Rattus norvegicus
Description:
ChEMBL_634760
Residue:
512
Sequence:
MAVAGAKRRAVAAPATTAAEEERQAREKMLEARRGDGADPEGEGVTLQRNITLINGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLSLVVWAVCGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPVFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFIQMGKDIGQGDASNLHQKLSFEGTNLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTNQMLTSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLMYAFSRDIFSIINFFSFFNWLCVALAIIGMMWLRFKKPELERPIKVNLALPVFFILACLFLIAVSFWKTPLECGIGFAIILSGLPVYFFGVWWKNKPKWILQVIFSVTVLCQKLMQVVPQET
  
Inhibitor
Name:
BDBM50319696
Synonyms:
(+/-)-2-endo-amino-bis(2-chloroethyl)-7'-aminobenzobicyclo[2.2.1]heptane-2-exo-carboxylicacid | CHEMBL1084596
Type:
Small organic molecule
Emp. Form.:
C16H20Cl2N2O2
Mol. Mass.:
343.248
SMILES:
NC1(CC2CC1c1cc(ccc21)N(CCCl)CCCl)C(O)=O |TLB:19:1:4:6.11,THB:10:11:1.2:4,7:6:1.2:4,0:1:4:6.11|
Structure:
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