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Target
Large neutral amino acids transporter small subunit 1
Ligand
BDBM50025836
Substrate
n/a
Meas. Tech.
ChEMBL_634760 (CHEMBL1119376)
Ki
25000±n/a nM
Citation
 Matharu, J; Oki, J; Worthen, DR; Smith, QR; Crooks, PA Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier. Bioorg Med Chem Lett 20:3688-91 (2010) [PubMed]  Article 
Target
Name:
Large neutral amino acids transporter small subunit 1
Synonyms:
L-type amino acid transporter 1 | LAT1_RAT | Lat1 | Mpe16 | Slc7a5 | Ta1
Type:
PROTEIN
Mol. Mass.:
55907.74
Organism:
Rattus norvegicus
Description:
ChEMBL_634760
Residue:
512
Sequence:
MAVAGAKRRAVAAPATTAAEEERQAREKMLEARRGDGADPEGEGVTLQRNITLINGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLSLVVWAVCGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPVFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFIQMGKDIGQGDASNLHQKLSFEGTNLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTNQMLTSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLMYAFSRDIFSIINFFSFFNWLCVALAIIGMMWLRFKKPELERPIKVNLALPVFFILACLFLIAVSFWKTPLECGIGFAIILSGLPVYFFGVWWKNKPKWILQVIFSVTVLCQKLMQVVPQET
  
Inhibitor
Name:
BDBM50025836
Synonyms:
(+/-)-2-amino-5-(bis(2-chloroethyl)amino)-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid | 2-Amino-5-[bis-(2-chloro-ethyl)-amino]-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid | CHEMBL345930
Type:
Small organic molecule
Emp. Form.:
C15H20Cl2N2O2
Mol. Mass.:
331.238
SMILES:
NC1(CCc2c(C1)cccc2N(CCCl)CCCl)C(O)=O
Structure:
Search PDB for entries with ligand similarity: