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Target
RAC-gamma serine/threonine-protein kinase
Ligand
BDBM50322393
Substrate
n/a
Meas. Tech.
ChEMBL_643117 (CHEMBL1176583)
IC50
12±n/a nM
Citation
Freeman-Cook, KD; Autry, C; Borzillo, G; Gordon, D; Barbacci-Tobin, E; Bernardo, V; Briere, D; Clark, T; Corbett, M; Jakubczak, J; Kakar, S; Knauth, E; Lippa, B; Luzzio, MJ; Mansour, M; Martinelli, G; Marx, M; Nelson, K; Pandit, J; Rajamohan, F; Robinson, S; Subramanyam, C; Wei, L; Wythes, M; Morris, J Design of selective, ATP-competitive inhibitors of Akt. J Med Chem 53:4615-22 (2010) [PubMed] Article
More Info.:
Target
Name:
RAC-gamma serine/threonine-protein kinase
Synonyms:
AKT3 | AKT3_HUMAN | PKB gamma | PKBG | Protein kinase Akt-3 | Protein kinase B (Akt 3) | Protein kinase B, gamma | RAC-PK-gamma | RAC-gamma serine/threonine-protein kinase | STK-2 | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT3
Type:
Enzyme
Mol. Mass.:
55769.36
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
479
Sequence:
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
Inhibitor
Name:
BDBM50322393
Synonyms:
(S)-N-((3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)methyl)-2,4-difluorobenzamide | CHEMBL1171647 | N-{[(3S)-3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl]methyl}-2,4-difluorobenzamide
Type:
Small organic molecule
Emp. Form.:
C20H22F2N6O
Mol. Mass.:
400.4251
SMILES:
CCc1c[nH]c2ncnc(N3CC[C@](N)(CNC(=O)c4ccc(F)cc4F)C3)c12 |r|