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Target
Melanocortin receptor 3
Ligand
BDBM50323158
Substrate
n/a
Meas. Tech.
ChEMBL_643828 (CHEMBL1212692)
IC50
4900±n/a nM
Citation
 Hong, Q; Bakshi, RK; Dellureficio, J; He, S; Ye, Z; Dobbelaar, PH; Sebhat, IK; Guo, L; Liu, J; Jian, T; Tang, R; Kalyani, RN; Macneil, T; Vongs, A; Rosenblum, CI; Weinberg, DH; Peng, Q; Tamvakopoulos, C; Miller, RR; Stearns, RA; Cashen, D; Martin, WJ; Chen, AS; Metzger, JM; Chen, HY; Strack, AM; Fong, TM; Maclntyre, E; Van der Ploeg, LH; Wyvratt, MJ; Nargund, RP Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands. Bioorg Med Chem Lett 20:4483-6 (2010) [PubMed]  Article 
Target
Name:
Melanocortin receptor 3
Synonyms:
MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4)
Type:
Enzyme
Mol. Mass.:
36044.86
Organism:
Homo sapiens (Human)
Description:
P41968
Residue:
323
Sequence:
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG
  
Inhibitor
Name:
BDBM50323158
Synonyms:
CHEMBL1209382 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)piperazin-1-yl)-4-methylpentyl)-N-isopropylmethane sulfonamide | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)piperazin-1-yl)-4-methylpentyl)-N-isopropylmethanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C29H48F2N4O3S
Mol. Mass.:
570.778
SMILES:
CC(C)CC(CN(C(C)C)S(C)(=O)=O)N1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C |r|
Structure:
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