Target
Melanocortin receptor 4
Ligand
BDBM50323157
Substrate
n/a
Meas. Tech.
ChEMBL_643823 (CHEMBL1212687)
IC50
150±n/a nM
Citation
 Hong, QBakshi, RKDellureficio, JHe, SYe, ZDobbelaar, PHSebhat, IKGuo, LLiu, JJian, TTang, RKalyani, RNMacneil, TVongs, ARosenblum, CIWeinberg, DHPeng, QTamvakopoulos, CMiller, RRStearns, RACashen, DMartin, WJChen, ASMetzger, JMChen, HYStrack, AMFong, TMMaclntyre, EVan der Ploeg, LHWyvratt, MJNargund, RP Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands. Bioorg Med Chem Lett 20:4483-6 (2010) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50323157
Synonyms:
CHEMBL1209383 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)piperazin-1-yl)-3,3-dimethylbutyl)-N-isopropyl acetamide | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)piperazin-1-yl)-3,3-dimethylbutyl)-N-isopropylacetamide
Type:
Small organic molecule
Emp. Form.:
C30H48F2N4O2
Mol. Mass.:
534.7245
SMILES:
CC(C)N(CC(N1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)C(C)(C)C)C(C)=O |r|
Structure:
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