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Target
Melanocortin receptor 4
Ligand
BDBM50323160
Substrate
n/a
Meas. Tech.
ChEMBL_643823 (CHEMBL1212687)
IC50
62.0±n/a nM
Citation
 Hong, Q; Bakshi, RK; Dellureficio, J; He, S; Ye, Z; Dobbelaar, PH; Sebhat, IK; Guo, L; Liu, J; Jian, T; Tang, R; Kalyani, RN; Macneil, T; Vongs, A; Rosenblum, CI; Weinberg, DH; Peng, Q; Tamvakopoulos, C; Miller, RR; Stearns, RA; Cashen, D; Martin, WJ; Chen, AS; Metzger, JM; Chen, HY; Strack, AM; Fong, TM; Maclntyre, E; Van der Ploeg, LH; Wyvratt, MJ; Nargund, RP Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands. Bioorg Med Chem Lett 20:4483-6 (2010) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50323160
Synonyms:
CHEMBL1209320 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)piperazin-1-yl)-2-cyclohexylethyl)-N,1-di isopropyl-1H-pyrazole-4-carboxamide | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)piperazin-1-yl)-2-cyclohexylethyl)-N,1-diisopropyl-1H-pyrazole-4-carboxamide
Type:
Small organic molecule
Emp. Form.:
C37H56F2N6O2
Mol. Mass.:
654.8763
SMILES:
CC(C)N(CC(C1CCCCC1)N1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)C(=O)c1cnn(c1)C(C)C |r|
Structure:
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