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Target
G-protein coupled estrogen receptor 1
Ligand
BDBM50303804
Substrate
n/a
Meas. Tech.
ChEMBL_648800 (CHEMBL1220639)
IC50
185±n/a nM
Citation
 Dennis, MK; Burai, R; Ramesh, C; Petrie, WK; Alcon, SN; Nayak, TK; Bologa, CG; Leitao, A; Brailoiu, E; Deliu, E; Dun, NJ; Sklar, LA; Hathaway, HJ; Arterburn, JB; Oprea, TI; Prossnitz, ER In vivo effects of a GPR30 antagonist. Nat Chem Biol 5:421-7 (2009) [PubMed]  Article 
Target
Name:
G-protein coupled estrogen receptor 1
Synonyms:
CEPR | CMKRL2 | DRY12 | G-protein coupled estrogen receptor 1 | G-protein-coupled receptor (GPR30 ) | GPER | GPER1 | GPER1_HUMAN | GPR30
Type:
PROTEIN
Mol. Mass.:
42259.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_982507
Residue:
375
Sequence:
MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLHERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFSSAV
  
Inhibitor
Name:
BDBM50303804
Synonyms:
(3aS,4R,9bR)-4-(6-bromobenzo[d][1,3]dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline | CHEMBL583543 | cid_3136844
Type:
Small organic molecule
Emp. Form.:
C19H16BrNO2
Mol. Mass.:
370.24
SMILES:
Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@@H]2C=CC[C@H]12 |r,c:22|
Structure:
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