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Target
Glutamate receptor 1
Ligand
BDBM50324448
Substrate
n/a
Meas. Tech.
ChEMBL_650216 (CHEMBL1219914)
IC50
83000±n/a nM
Citation
 Mosley, CA; Acker, TM; Hansen, KB; Mullasseril, P; Andersen, KT; Le, P; Vellano, KM; Bräuner-Osborne, H; Liotta, DC; Traynelis, SF Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. J Med Chem 53:5476-90 (2010) [PubMed]  Article 
Target
Name:
Glutamate receptor 1
Synonyms:
AMPA-selective glutamate receptor 1 | GRIA1_RAT | GluA1 | GluR-1 | GluR-A | GluR-K1 | Glur1 | Glutamate receptor ionotropic, AMPA 1 | Gria1
Type:
Protein
Mol. Mass.:
101583.91
Organism:
Rattus norvegicus (Rat)
Description:
P19490
Residue:
907
Sequence:
MPYIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARIMQQWRTSDSRDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQQSINEAIRTSTLPRNSGAGASGGGGSGENGRVVSQDFPKSMQSIPCMSHSSGMPLGATGL
  
Inhibitor
Name:
BDBM50324448
Synonyms:
(E)-6-iodo-2-(2-(pyridin-3-yl)vinyl)-3-o-tolylquinazolin-4(3H)-one | CHEMBL1214868
Type:
Small organic molecule
Emp. Form.:
C22H16IN3O
Mol. Mass.:
465.2864
SMILES:
Cc1ccccc1-n1c(\C=C\c2cccnc2)nc2ccc(I)cc2c1=O |(9.99,-8.67,;11.33,-9.43,;12.66,-8.66,;14.01,-9.42,;14.01,-10.96,;12.68,-11.74,;11.34,-10.97,;10.01,-11.74,;10.02,-13.28,;11.36,-14.05,;11.36,-15.59,;12.69,-16.36,;14.01,-15.58,;15.35,-16.34,;15.35,-17.89,;14.02,-18.66,;12.69,-17.9,;8.68,-14.06,;7.35,-13.29,;6,-14.07,;4.67,-13.3,;4.67,-11.76,;3.34,-10.99,;6,-10.98,;7.34,-11.75,;8.67,-10.97,;8.66,-9.43,)|
Structure:
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