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Target
Coagulation factor X
Ligand
BDBM50324743
Substrate
n/a
Meas. Tech.
ChEMBL_651365 (CHEMBL1227185)
Ki
3.3±n/a nM
Citation
 Anselm, L; Banner, DW; Benz, J; Zbinden, KG; Himber, J; Hilpert, H; Huber, W; Kuhn, B; Mary, JL; Otteneder, MB; Panday, N; Ricklin, F; Stahl, M; Thomi, S; Haap, W Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide] as a clinical candidate. Bioorg Med Chem Lett 20:5313-9 (2010) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
F10 | FA10_RABIT
Type:
PROTEIN
Mol. Mass.:
53951.21
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_1471174
Residue:
490
Sequence:
MANPLHLVLLGAALAGLLLSGSSVFISRRAANDVLARTRRANSFLEELKKGNLERECMEENCSYEEALEVFEDREKTNEFWNKYVDGDQCESNPCQNQGTCKDGLGMYTCSCVEGYEGQDCEPVTRKLCSLDNGGCDQFCKEEENSVLCSCASGYTLGDNGKSCISTELFPCGKVTLGRWRRSPATNSSEGPPEAPGPEQQDDGNLTATENPFNLLDSPEPPPEDDSSSLVRIVGGQDCRDGECPWQALLVNEENEGFCGGTILSEYHVLTAAHCLHQAKRFKVRVGDRDTEHEEGNEETHEVEVVVKHNRFVKETYDFDIAVLRLKTPITFRRNVAPACLPQKDWAESTLMAQKTGIVSGFGRTHEMGRLSTTLKMLEVPYVDRNSCKRSSSFTITQNMFCAGYDARPEDACQGDSGGPHVTRFRDTYFVTGIVSWGEGCARKGKFGVYTKVSNFLKWIEKSMRARAVPVAEAAGTPGPTQPTIKGSPS
  
Inhibitor
Name:
BDBM50324743
Synonyms:
(3R,4R)-1-(2,2-DIFLUORO-ETHYL)-PYRROLIDINE-3,4-DICARBOXYLIC ACID 3-[(5-CHLORO-PYRIDIN-2-YL)-AMIDE]-4-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYL]-AMIDE} | (3R,4R)-N3-(5-chloropyridin-2-yl)-1-(2,2-difluoroethyl)-N4-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)pyrrolidine-3,4-dicarboxamide | CHEMBL1221913
Type:
Small organic molecule
Emp. Form.:
C24H21ClF3N5O3
Mol. Mass.:
519.903
SMILES:
FC(F)CN1C[C@@H]([C@H](C1)C(=O)Nc1ccc(cc1F)-n1ccccc1=O)C(=O)Nc1ccc(Cl)cn1 |r|
Structure:
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