Reaction Details Report a problem with these data
Target
Hydroxycarboxylic acid receptor 2
Ligand
BDBM50325922
Substrate
n/a
Meas. Tech.
ChEMBL_652725 (CHEMBL1225928)
IC50
2700±n/a nM
Citation
 Peters, JU; Kühne, H; Dehmlow, H; Grether, U; Conte, A; Hainzl, D; Hertel, C; Kratochwil, NA; Otteneder, M; Narquizian, R; Panousis, CG; Ricklin, F; Röver, S Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity. Bioorg Med Chem Lett 20:5426-30 (2010) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 2
Synonyms:
Gpr109 | Gpr109a | Gpr109b | HCAR2_RAT | HM74 nicotinic acid GPCR | Hcar2 | Niacr1 | Pumag
Type:
PROTEIN
Mol. Mass.:
41476.06
Organism:
Rattus norvegicus
Description:
ChEMBL_820675
Residue:
360
Sequence:
MSKQNHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVQNWDWRFGSIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGITIGLTVHLLYTDMMTRNGDANLCSSFSICYTFRWHDAMFLLEFFLPLGIILFCSGRIIWSLRQRQMDRHVKIKRAINFIMVVAIVFVICFLPSVAVRIRIFWLLYKHNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRRKTLGEPDNNRSTSVELTGDPSTIRSIPGALMTDPSEPGSPPYLASTSR
  
Inhibitor
Name:
BDBM50325922
Synonyms:
2-((4-fluorophenethyloxy)methyl)pyrido[2,3-d]pyrimidin-4(3H)-one | CHEMBL1224147
Type:
Small organic molecule
Emp. Form.:
C16H14FN3O2
Mol. Mass.:
299.2997
SMILES:
Fc1ccc(CCOCc2nc3ncccc3c(=O)[nH]2)cc1
Structure:
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