Compile Data Set for Download or QSAR
maximum 50k data
Found 584 with Last Name = 'hainzl' and Initial = 'd'
TargetNociceptin receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188855(1-phenyl-8-(1-phenyl-cyclohexyl)-1,3,8-triaza-spir...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]NOP from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325913(2-(3-(2-chlorophenoxy)propoxy)pyrido[2,3-d]pyrimid...)
Affinity DataIC50:  15nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188855(1-phenyl-8-(1-phenyl-cyclohexyl)-1,3,8-triaza-spir...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]naloxone from mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325914(2-(3-(3-chlorophenoxy)propoxy)pyrido[2,3-d]pyrimid...)
Affinity DataIC50:  33nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325924(2-((3-chlorophenethyloxy)methyl)pyrido[2,3-d]pyrim...)
Affinity DataIC50:  50nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325908(2-(3-phenoxypropoxy)pyrido[2,3-d]pyrimidin-4(3H)-o...)
Affinity DataIC50:  130nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188374(1-phenyl-8-(2-phenyl-cyclohexyl)-1,3,8-triaza-spir...)
Affinity DataIC50:  150nMAssay Description:Displacement of [3H]naloxone from human mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50263360(CHEMBL476555 | N-(2-(7-chloro-1-methyl-2-oxo-5-phe...)
Affinity DataIC50:  154nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325920(2-((2-fluorophenethyloxy)methyl)pyrido[2,3-d]pyrim...)
Affinity DataIC50:  220nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325915(2-(3-(4-chlorophenoxy)propoxy)pyrido[2,3-d]pyrimid...)
Affinity DataIC50:  230nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325921(2-((3-fluorophenethyloxy)methyl)pyrido[2,3-d]pyrim...)
Affinity DataIC50:  230nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325910(2-(3-(2-fluorophenoxy)propoxy)pyrido[2,3-d]pyrimid...)
Affinity DataIC50:  250nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325907(2-(cinnamyloxy)pyrido[2,3-d]pyrimidin-4(3H)-one | ...)
Affinity DataIC50:  370nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325911(2-(3-(3-fluorophenoxy)propoxy)pyrido[2,3-d]pyrimid...)
Affinity DataIC50:  370nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Rattus norvegicus)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325899(2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-on...)
Affinity DataIC50:  400nMAssay Description:Displacement of radioligand from rat GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325927(2-(2-m-Tolyl-ethoxymethyl)-3H-pyrido[2,3-d]pyrimid...)
Affinity DataIC50:  410nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325926(2-(2-o-Tolyl-ethoxymethyl)-3H-pyrido[2,3-d]pyrimid...)
Affinity DataIC50:  440nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325916(2-(3-(o-tolyloxy)propoxy)pyrido[2,3-d]pyrimidin-4(...)
Affinity DataIC50:  450nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50265098(4-(4-(2-(cyclopropylmethoxy)-5-(methylsulfonyl)ben...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human ERG potassium channel by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50265098(4-(4-(2-(cyclopropylmethoxy)-5-(methylsulfonyl)ben...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325923(2-((2-chlorophenethyloxy)methyl)pyrido[2,3-d]pyrim...)
Affinity DataIC50:  600nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325922(2-((4-fluorophenethyloxy)methyl)pyrido[2,3-d]pyrim...)
Affinity DataIC50:  630nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Rattus norvegicus)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325924(2-((3-chlorophenethyloxy)methyl)pyrido[2,3-d]pyrim...)
Affinity DataIC50:  640nMAssay Description:Displacement of radioligand from rat GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325900(2-((phenethyloxy)methyl)pyrido[2,3-d]pyrimidin-4(3...)
Affinity DataIC50:  670nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50322424(3-Fluoro-4-[4-(2-isobutoxy-5-methanesulfonyl-benzo...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325896(2-(4-phenylbutoxy)pyrido[2,3-d]pyrimidin-4(3H)-one...)
Affinity DataIC50:  840nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325917(2-(3-(m-tolyloxy)propoxy)pyrido[2,3-d]pyrimidin-4(...)
Affinity DataIC50:  860nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325909(CHEMBL1223958 | N-((3,4-dihydro-4-oxopyrido[2,3-d]...)
Affinity DataIC50:  920nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325912(2-(3-(4-fluorophenoxy)propoxy)pyrido[2,3-d]pyrimid...)
Affinity DataIC50:  1.10E+3nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325925(2-((4-chlorophenethyloxy)methyl)pyrido[2,3-d]pyrim...)
Affinity DataIC50:  1.20E+3nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50322428(CHEMBL1171498 | rac-4-{4-[5-Methanesulfonyl-2-(2,2...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325899(2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-on...)
Affinity DataIC50:  1.30E+3nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188849(4-(4-fluoro-phenyl)-8-[1-(4-fluoro-phenyl)-cyclohe...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of hERG potassium channel expressed in CHO cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Rattus norvegicus)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325913(2-(3-(2-chlorophenoxy)propoxy)pyrido[2,3-d]pyrimid...)
Affinity DataIC50:  1.40E+3nMAssay Description:Displacement of radioligand from rat GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188803((S)-4-phenyl-8-((1R,2R)-2-phenyl-cyclohexyl)-2,8-d...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of hERG potassium channel expressed in CHO cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325930(2-((3-methoxyphenethyloxy)methyl)pyrido[2,3-d]pyri...)
Affinity DataIC50:  1.50E+3nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325929(2-((2-methoxyphenethyloxy)methyl)pyrido[2,3-d]pyri...)
Affinity DataIC50:  1.70E+3nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188364(8-[2-(4-fluoro-phenyl)-2-hydroxy-cyclohexyl]-4-phe...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of hERG potassium channel expressed in CHO cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50322426(3-Fluoro-4-{4-[5-methanesulfonyl-2-(2,2,2-trifluor...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188376(8-(2-hydroxy-2-phenyl-cyclohexyl)-1-phenyl-1,3,8-t...)
Affinity DataIC50:  2.70E+3nMAssay Description:Displacement of [3H]naloxone from human mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Rattus norvegicus)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325922(2-((4-fluorophenethyloxy)methyl)pyrido[2,3-d]pyrim...)
Affinity DataIC50:  2.70E+3nMAssay Description:Displacement of radioligand from rat GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188843(8-(1-phenyl-cyclohexyl)-4-propyl-2,8-diaza-spiro[4...)
Affinity DataIC50:  2.73E+3nMAssay Description:Displacement of [3H]naloxone from mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188843(8-(1-phenyl-cyclohexyl)-4-propyl-2,8-diaza-spiro[4...)
Affinity DataIC50:  2.76E+3nMAssay Description:Displacement of [3H]naloxone from mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188843(8-(1-phenyl-cyclohexyl)-4-propyl-2,8-diaza-spiro[4...)
Affinity DataIC50:  2.76E+3nMAssay Description:Displacement of [3H]naloxone from mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50322427(CHEMBL1172999 | rac-Fluoro-4-{4-[5-methanesulfonyl...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188879(CHEMBL214057 | rac-8-[1-(4-fluoro-phenyl)-cyclohex...)
Affinity DataIC50:  3.03E+3nMAssay Description:Displacement of [3H]naloxone from mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50322425(3-Fluoro-4-[4-(2-isopropoxy-5-methanesulfonyl-benz...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188859(CHEMBL378665 | rac-4-(4-fluoro-phenyl)-8-(1-o-toly...)
Affinity DataIC50:  3.85E+3nMAssay Description:Displacement of [3H]naloxone from mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188803((S)-4-phenyl-8-((1R,2R)-2-phenyl-cyclohexyl)-2,8-d...)
Affinity DataIC50:  3.92E+3nMAssay Description:Displacement of [3H]naloxone from human mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50325928(2-(2-p-Tolyl-ethoxymethyl)-3H-pyrido[2,3-d]pyrimid...)
Affinity DataIC50:  4.30E+3nMAssay Description:Displacement of radioligand from human GPR109AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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