Reaction Details Report a problem with these data
Target
Cyclin-dependent protein kinase PHO85/PHO85 cyclin PHO80/Phosphate system positive regulatory protein PHO81
Ligand
BDBM50326018
Substrate
n/a
Meas. Tech.
ChEMBL_654965 (CHEMBL1244009)
Ki
19000±n/a nM
Citation
 Lee, YS; Huang, K; Quiocho, FA; O'Shea, EK Molecular basis of cyclin-CDK-CKI regulation by reversible binding of an inositol pyrophosphate. Nat Chem Biol 4:25-32 (2007) [PubMed]  Article 
Target
Name:
Cyclin-dependent protein kinase PHO85/PHO85 cyclin PHO80/Phosphate system positive regulatory protein PHO81
Synonyms:
Cyclin-dependent protein kinase PHO85
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 654965
Components:
This complex has 1 components.
Component 1
Name:
Cyclin-dependent protein kinase PHO85
Synonyms:
Cyclin-dependent protein kinase PHO85 | PHO85 | PHO85_YEAST | Pho80/Pho85 | SSG3
Type:
PROTEIN
Mol. Mass.:
34912.85
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_563813
Residue:
305
Sequence:
MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS
  
Component 2
Name:
Phosphate system positive regulatory protein PHO81
Synonyms:
CDK inhibitor PHO81 | PHO81 | PHO81_YEAST
Type:
PROTEIN
Mol. Mass.:
134012.60
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_654961
Residue:
1178
Sequence:
MKFGKYLEARQLELAEYNSHFIDYKALKKLIKQLAIPTLKASSDLDLHLTLDDIDEKIIHQRLQENKAAFFFKLERELEKVNGYYLARESDLRIKFNILHSKYKDYKINGKLNSNQATSFKNLYAAFKKFQKDLRNLEQYVELNKTGFSKALKKWDKRSQSHDKDFYLATVVSIQPIFTRDGPLKLNDETLHILLELNDIDNNNRRADIQSSTFTNDDDDDNNTSNNNKHNNNNNNNNNNNNNNNNNNILHNNYELTTSKISENQLEHLFQASSSSLDMEMEIENWYKEILNIATVKDVQRKHALLRNFRETKIFTYLLQNSSESFHKNVFSLLKECLTTLFLLLVASPLDDNSLHIFYKSNQDHIDLSYCDEDDQVFSRKNVFHEAASCPEKSRLFILDEALTTSKLSKETVQKLLNAQDIHSRVPLHYAAELGKLEFVHSLLITNLLEDVDPIDSDSKTPLVLAITNNHIDVVRDLLTIGGANASPIEKPILDYSKNVISSTKVQFDPLNVACKFNNHDAAKLLLEIRSKQNADNAKNKSSQHLCQPLFKKNSTGLCTLHIVAKIGGDPQLIQLLIRYGADPNEIDGFNKWTPIFYAVRSGHSEVITELLKHNARLDIEDDNGHSPLFYALWESHVDVLNALLQRPLNLPSAPLNEINSQSSTQRLNTIDLTPNDDKFDLDIQDSIPDFALPPPIIPLRKYGHNFLEKKIFIKLKLRPGLESIKLTQDNGIIMSSSPGRITLSSNLPEIIPRNVILPVRSGEINNFCKDISETNDEEDDDEISEDHDDGEIIFQVDSIDDFSMDFEIFPSFGTRIIAKTTAMPFLFKKVAINSIATMNLPLFDTRLNNIGSLTLDYQIIFPYPGNPLKIINYEPYWKSTGSDLMTSSKDGNFVTSSSLNGSFISVLVCALNDETIVAAPKPYVEFKGTKILLNDLTKEQLEKVVDYDFGKIDGSFDEVTLKQYLSSRVVPLRSLLEVIPGSAQLVIRVYFPTDKEIDTIPIKISPFININQFIDKLLLIIFEHERFLRHSGSGSMRQIVFSSCNWEACSILNWKQPNFPVLLQMKNLLRDSTTGKFVGDTPNCLKELAVNPQKMSYLNTELINIHTMVQFAMNNNLLGVTLPYEVLKICPSLARIIKQNGLLLIASVGENDQIPADGGYSGIYYACELLFENNIDM
  
Component 3
Name:
PHO85 cyclin PHO80
Synonyms:
AGS3 | Aminoglycoside antibiotic sensitivity protein 3 | PHO80 | PHO80_YEAST | Phosphate system cyclin PHO80 | TUP7 | VAC5
Type:
PROTEIN
Mol. Mass.:
33238.94
Organism:
Saccharomyces cerevisiae
Description:
EBI_103488
Residue:
293
Sequence:
MESTSGERSENIHEDQGIPKVILPADFNKCSRTDLVVLISRMLVSLIAINENSATKKSDDQITLTRYHSKIPPNISIFNYFIRLTKFSSLEHCVLMTSLYYIDLLQTVYPDFTLNSLTAHRFLLTATTVATKGLCDSFSTNAHYAKVGGVRCHELNILENDFLKRVNYRIIPRDHNITLCSIEQKQKKFVIDKNALGSLDLDSYSYVNRPKSGYNVLDKYYRRIVQLVGSFNASPDKSRKVDYVLPPNIDIVSESGSQTTQLKGSSSPNSHSSQKRYSEAKDAHIYNKRSKPD
  
Inhibitor
Name:
BDBM50326018
Synonyms:
(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyldiphosphoric acid | CHEMBL1242023
Type:
Small organic molecule
Emp. Form.:
C6H19O27P7
Mol. Mass.:
740.0152
SMILES:
OP(O)(=O)O[C@@H]1[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(=O)OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: