Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50327314
Substrate
n/a
Meas. Tech.
ChEMBL_664372 (CHEMBL1259521)
Ki
14±n/a nM
Citation
 Walter, M; von Coburg, Y; Isensee, K; Sander, K; Ligneau, X; Camelin, JC; Schwartz, JC; Stark, H Azole derivatives as histamine H3 receptor antagonists, part I: thiazol-2-yl ethers. Bioorg Med Chem Lett 20:5879-82 (2010) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50327314
Synonyms:
5-ethyl-2-(3-(piperidin-1-yl)propoxy)-4,5,6,7-tetrahydrothiazolo[4,5-c]pyridine | CHEMBL1257353
Type:
Small organic molecule
Emp. Form.:
C16H27N3OS
Mol. Mass.:
309.47
SMILES:
CCN1CCc2sc(OCCCN3CCCCC3)nc2C1
Structure:
Search PDB for entries with ligand similarity: