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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50327408
Substrate
n/a
Meas. Tech.
ChEMBL_664469 (CHEMBL1259851)
IC50
16±n/a nM
Citation
 Lin, S; Wrobleski, ST; Hynes, J; Pitt, S; Zhang, R; Fan, Y; Doweyko, AM; Kish, KF; Sack, JS; Malley, MF; Kiefer, SE; Newitt, JA; McKinnon, M; Trzaskos, J; Barrish, JC; Dodd, JH; Schieven, GL; Leftheris, K Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38a MAP kinase inhibitors. Bioorg Med Chem Lett 20:5864-8 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50327408
Synonyms:
5-(6-(2-chlorophenyl)-2-(pyridin-2-yl)pyrimidin-4-yl)-N-cyclobutylthiazol-2-amine | CHEMBL1258632
Type:
Small organic molecule
Emp. Form.:
C22H18ClN5S
Mol. Mass.:
419.93
SMILES:
Clc1ccccc1-c1cc(nc(n1)-c1ccccn1)-c1cnc(NC2CCC2)s1
Structure:
Search PDB for entries with ligand similarity: