Reaction Details Report a problem with these data
Target
Proline-rich AKT1 substrate 1
Ligand
BDBM50327790
Substrate
n/a
Meas. Tech.
ChEMBL_664853 (CHEMBL1259577)
IC50
160±n/a nM
Citation
Blake, JF; Kallan, NC; Xiao, D; Xu, R; Bencsik, JR; Skelton, NJ; Spencer, KL; Mitchell, IS; Woessner, RD; Gloor, SL; Risom, T; Gross, SD; Martinson, M; Morales, TH; Vigers, GP; Brandhuber, BJ Discovery of pyrrolopyrimidine inhibitors of Akt. Bioorg Med Chem Lett 20:5607-12 (2010) [PubMed] Article
More Info.:
Target
Name:
Proline-rich AKT1 substrate 1
Synonyms:
40 kDa proline-rich AKT substrate | AKT1S1 | AKTS1_HUMAN | PRAS40
Type:
PROTEIN
Mol. Mass.:
27368.40
Organism:
Homo sapiens (Human)
Description:
ChEMBL_664853
Residue:
256
Sequence:
MASGRPEELWEAVVGAAERFRARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARRCLHDIALAHRAATAARPPAPPPAPQPPSPTPSPPRPTLAREDNEEDEDEPTETETSGEQLGISDNGGLFVMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPPTCSVPPASALPTQQYAKSLPVSVPVWGFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDTQVFGDLPRPRLNTSDFQKLKRKY
Inhibitor
Name:
BDBM50327790
Synonyms:
(R)-2-amino-3-(4-fluorophenyl)-1-(4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one | CHEMBL1257282
Type:
Small organic molecule
Emp. Form.:
C20H23FN6O
Mol. Mass.:
382.4346
SMILES:
Cc1c[nH]c2ncnc(N3CCN(CC3)C(=O)[C@H](N)Cc3ccc(F)cc3)c12 |r|