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Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM50328554
Substrate
n/a
Meas. Tech.
ChEMBL_665678 (CHEMBL1261609)
IC50
223±n/a nM
Citation
Zhou, C; Garcia-Calvo, M; Pinto, S; Lombardo, M; Feng, Z; Bender, K; Pryor, KD; Bhatt, UR; Chabin, RM; Geissler, WM; Shen, Z; Tong, X; Zhang, Z; Wong, KK; Roy, RS; Chapman, KT; Yang, L; Xiong, Y Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity. J Med Chem 53:7251-63 (2010) [PubMed] Article
More Info.:
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
Angiotensinase C | Lysosomal carboxypeptidase C | PCP | PCP_HUMAN | PRCP | Proline carboxypeptidase | Prolylcarboxypeptidase | Prolylcarboxypeptidase (PRCP)
Type:
Enzyme
Mol. Mass.:
55805.19
Organism:
Homo sapiens (Human)
Description:
P42785
Residue:
496
Sequence:
MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH