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Found 1135 with Last Name = 'garcia-calvo' and Initial = 'm'
TargetCaspase-3(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataKi:  0.230nM ΔG°:  -55.0kJ/molepH: 7.5 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50174298(3-(4-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)bicy...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50089636(CHEMBL3578271)
Affinity DataKi:  2nMAssay Description:Binding affinity to mineralocorticoid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50340378(3-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116264((S)-3-({(S)-(S)-5-[(S)-2-((S)-Acetyl-methyl-amino)...)
Affinity DataKi:  7nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50435691(CHEMBL2391968)
Affinity DataKi:  7nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116262((2S,5S)-5-[(S)-2-(2-Benzo[b]thiophen-3-yl-acetylam...)
Affinity DataKi:  7nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116260((R)-2-({(2S,5S)-5-[(S)-2-(Acetyl-methyl-amino)-3-(...)
Affinity DataKi:  8nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116256((S)-3-({1-[(S)-2-((3S,4S)-2-Acetylamino-3-methyl-p...)
Affinity DataKi:  13nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50340386(3-(4-(ethylsulfonylmethyl)bicyclo[2.2.2]octan-1-yl...)
Affinity DataKi:  13nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116255((2S,5S)-5-((S)-3-(S)-Methyl-2-phenylacetylamino-pe...)
Affinity DataKi:  13nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116267((S)-3-({(S)-(S)-5-[(S)-2-((S)-Acetyl-methyl-amino)...)
Affinity DataKi:  16nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataKi:  18nM ΔG°:  -44.2kJ/molepH: 7.5 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM50116264((S)-3-({(S)-(S)-5-[(S)-2-((S)-Acetyl-methyl-amino)...)
Affinity DataKi:  26nMAssay Description:Compound was tested for its inhibition against Caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116268((2S,5S)-5-[(S)-2-(Acetyl-methyl-amino)-3-(S)-methy...)
Affinity DataKi:  38nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM50116260((R)-2-({(2S,5S)-5-[(S)-2-(Acetyl-methyl-amino)-3-(...)
Affinity DataKi:  71nMAssay Description:Compound was tested for its inhibition against Caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116269((2S,5S)-5-[(S)-2-(Acetyl-methyl-amino)-3-(S)-methy...)
Affinity DataKi:  74nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116261((2S,5S)-5-((R)-3-Methyl-2-pyridin-2-yl-butyrylamin...)
Affinity DataKi:  75nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116259((S)-4-((3S,4S)-2-Acetylamino-3-methyl-pentanoylami...)
Affinity DataKi:  80nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116265((S)-3-({(S)-(S)-5-[(S)-2-((S)-Acetyl-methyl-amino)...)
Affinity DataKi:  85nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116263((S)-3-{[(S)-(5S,7S)-6-((3S,4S)-2-Acetylamino-3-met...)
Affinity DataKi:  122nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116258((S)-3-{2-[3-((2S,3S)-2-Acetylamino-3-methyl-pentan...)
Affinity DataKi:  133nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM50116265((S)-3-({(S)-(S)-5-[(S)-2-((S)-Acetyl-methyl-amino)...)
Affinity DataKi:  143nMAssay Description:Compound was tested for its inhibition against Caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM50116267((S)-3-({(S)-(S)-5-[(S)-2-((S)-Acetyl-methyl-amino)...)
Affinity DataKi:  202nMAssay Description:Compound was tested for its inhibition against Caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116257(3-[((S)-{1-[(S)-2-((3S,4S)-2-Acetylamino-3-methyl-...)
Affinity DataKi:  270nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116260((R)-2-({(2S,5S)-5-[(S)-2-(Acetyl-methyl-amino)-3-(...)
Affinity DataKi:  350nMAssay Description:Compound was tested for its inhibition against Caspase-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116270((2S,5S)-5-[(S)-2-(Acetyl-methyl-amino)-3-(S)-methy...)
Affinity DataKi:  360nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116254(3-({(S)-(S)-5-[(S)-2-((S)-Acetyl-methyl-amino)-3-m...)
Affinity DataKi:  580nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116266((S)-3-({(S)-(S)-5-[(S)-2-((S)-Acetyl-methyl-amino)...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition against human granzyme BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364407(CHEMBL1950444)
Affinity DataIC50:  0.0390nMAssay Description:Inhibition of mouse recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate for 30 mins by continuous fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50443348(CHEMBL3086040 | US8669252, 12)
Affinity DataIC50:  0.0790nMAssay Description:Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364689(CHEMBL1951478)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of mouse PrCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364386(CHEMBL1950440)
Affinity DataIC50:  0.170nMAssay Description:Inhibition of human recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate for 30 mins by continuous fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50443351(CHEMBL3086037 | US8669252, 15)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364676(CHEMBL1951465 | US8785634, 1)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of mouse PrCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50383421(CHEMBL2031595)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of mouse PrCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50382913(CHEMBL2023210)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human PrCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50382899(CHEMBL2022787)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human PrCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50382904(CHEMBL2022793)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human PrCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50443348(CHEMBL3086040 | US8669252, 12)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of recombinant mouse PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50382906(CHEMBL2023202)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human PrCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50361786(CHEMBL1938522)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50382906(CHEMBL2023202)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human PrCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50382913(CHEMBL2023210)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of mouse PrCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364685(CHEMBL1951474)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of mouse PrCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364407(CHEMBL1950444)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of human recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate for 30 mins by continuous fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364679(CHEMBL1951468 | US8785634, 2)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of mouse PrCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50364687(CHEMBL1951476 | US8785634, 8)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of mouse PrCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50382906(CHEMBL2023202)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of mouse PrCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal Pro-X carboxypeptidase(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50383427(CHEMBL2031588)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of mouse PrCPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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