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Target
Cholecystokinin receptor type A
Ligand
BDBM50329184
Substrate
n/a
Meas. Tech.
ChEMBL_674620 (CHEMBL1273767)
IC50
15±n/a nM
Citation
 Elliott, RL; Cameron, KO; Chin, JE; Bartlett, JA; Beretta, EE; Chen, Y; Jardine, Pda S; Dubins, JS; Gillaspy, ML; Hargrove, DM; Kalgutkar, AS; LaFlamme, JA; Lame, ME; Martin, KA; Maurer, TS; Nardone, NA; Oliver, RM; Scott, DO; Sun, D; Swick, AG; Trebino, CE; Zhang, Y Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity. Bioorg Med Chem Lett 20:6797-801 (2010) [PubMed]  Article 
Target
Name:
Cholecystokinin receptor type A
Synonyms:
CCK-A receptor | CCK-AR | CCK1-R | CCKAR | CCKAR_HUMAN | CCKRA | Cholecystokinin receptor | Cholecystokinin receptor type A | Cholecystokinin-1 Receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
47859.34
Organism:
Homo sapiens (Human)
Description:
Stable expression of human CCK-1 receptors in HEK 293 cells.
Residue:
428
Sequence:
MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSHMSASVPPQ
  
Inhibitor
Name:
BDBM50329184
Synonyms:
CHEMBL1269262 | N-benzyl-N-isopropyl-2-(5-oxo-4-phenoxy-1-phenyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)acetamide
Type:
Small organic molecule
Emp. Form.:
C34H31N5O3
Mol. Mass.:
557.6416
SMILES:
CC(C)N(Cc1ccccc1)C(=O)CN1c2ccccc2-n2c(nnc2-c2ccccc2)C(Oc2ccccc2)C1=O
Structure:
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