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Found 618 with Last Name = 'elliott' and Initial = 'rl'
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117772(CHEMBL10921 | N-(2-Diethylamino-ethyl)-2-[2-(4-flu...)
Affinity DataKi:  0.0300nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50128931(CHEMBL61880 | N-(9-Isobutyl-9H-carbazol-3-yl)-3-py...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity towards human neuropeptide Y receptor type 5 using 125[I]-PYY as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613695(CHEMBL5274166)
Affinity DataKi:  0.350nMAssay Description:Inhibition of human EGFR T790M/del (746 to 750 residues) mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 peptide as subs...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583347(CHEMBL5080055)
Affinity DataKi:  0.400nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583341(CHEMBL5092805)
Affinity DataKi:  0.470nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM172639(US9090628, 299)
Affinity DataKi:  0.480nMAssay Description:Binding affinity to PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367254(ENALAPRILAT)
Affinity DataKi:  0.5nMAssay Description:Binding affinity towards Angiotensin I converting enzyme of rat brain IgG immobilized enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17156(3-(4-{[3-(3-methoxy-4-{[(2-methylphenyl)carbamoyl]...)
Affinity DataKi:  0.5nM ΔG°:  -52.6kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613688(CHEMBL5282716)
Affinity DataKi: <0.600nMAssay Description:Inhibition of human EGFR T790M/L858R double mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as peptide substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613687(CHEMBL5285503)
Affinity DataKi: <0.600nMAssay Description:Inhibition of human EGFR T790M/L858R double mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as peptide substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM172634(US9090628, 294)
Affinity DataKi:  0.780nMAssay Description:Binding affinity to PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17169((3R)-3-(4-{[3-(3-methoxy-4-{[(2-methylphenyl)carba...)
Affinity DataKi:  0.790nM ΔG°:  -51.4kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17175((3R)-3-(4-{[3-(2-chloro-4-{[(2-methylphenyl)carbam...)
Affinity DataKi:  0.790nMAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613684(CHEMBL5280555)
Affinity DataKi:  0.790nMAssay Description:Inhibition of human EGFR T790M/L858R double mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as peptide substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50278665(CHEMBL4175041)
Affinity DataKi:  0.810nMAssay Description:Binding affinity to PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50128927(CHEMBL59680 | N-(9-Ethyl-9H-carbazol-3-yl)-3-morph...)
Affinity DataKi:  0.840nMAssay Description:Binding affinity towards human neuropeptide Y receptor type 5 using 125[I]-PYY as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM172640(US9090628, 300)
Affinity DataKi:  0.880nMAssay Description:Binding affinity to PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17167((3R)-3-(4-{[3-(4-{[(2-methylphenyl)carbamoyl]amino...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17174((3R)-3-(4-{[3-(3-methyl-4-{[(2-methylphenyl)carbam...)
Affinity DataKi:  1nMAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17170((3R)-3-(4-{[3-(3-chloro-4-{[(2-methylphenyl)carbam...)
Affinity DataKi:  1nMAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17168((3S)-3-(4-{[3-(3-methoxy-4-{[(2-methylphenyl)carba...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613698(CHEMBL5282384)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human EGFR T790M/L858R double mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as peptide substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613695(CHEMBL5274166)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human EGFR T790M/L858R double mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as peptide substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123737(3-{2-[6-(2-tert-Butoxy-ethoxy)-pyridin-3-yl]-3H-im...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity of the compound to the human Neuropeptide Y receptor type 5 was determined using [125I]- [PYY] as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50278667(CHEMBL4167171)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613695(CHEMBL5274166)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human EGFR del (746 to 750) mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613686(CHEMBL5276357)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human EGFR T790M/L858R double mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as peptide substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613699(CHEMBL5279275)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human EGFR T790M/L858R double mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as peptide substrate preincu...More data for this Ligand-Target Pair
Ligand InfoPDB
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613699(CHEMBL5279275)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human EGFR del (746 to 750) mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPDB
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583348(CHEMBL5093381)
Affinity DataKi:  1.5nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50128943(9-Ethyl-3-(3H-imidazo[4,5-b]pyridin-2-yl)-9H-carba...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity towards human neuropeptide Y receptor type 5 using 125[I]-PYY as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17154(3-{4-[(3-{3-methoxy-4-[(phenylcarbamoyl)amino]phen...)
Affinity DataKi:  1.58nM ΔG°:  -49.7kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613699(CHEMBL5279275)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human EGFR T790M/del (746 to 750 residues) mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 peptide as subs...More data for this Ligand-Target Pair
Ligand InfoPDB
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50133761(3-[5-(3-Trifluoromethyl-phenyl)-1H-imidazol-2-yl]-...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity towards human neuropeptide Y receptor type 5 using [125I]-PYY as radiogigand in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Rat 6B)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123737(3-{2-[6-(2-tert-Butoxy-ethoxy)-pyridin-3-yl]-3H-im...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity of the compound to the rat Neuropeptide Y receptor type 5 was determined using [125I]- [Leu31,Pro34]PYY as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM172467(US9090628, 110)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613693(CHEMBL5281373)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human EGFR T790M/del (746 to 750 residues) mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 peptide as subs...More data for this Ligand-Target Pair
Ligand InfoPDB
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583331(CHEMBL5089907)
Affinity DataKi:  1.80nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM172643(US9090628, 303)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17164(3-(4-{[3-(4-{[(2,6-dimethylphenyl)carbamoyl]amino}...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17172((3R)-3-(4-{[3-(3-ethoxy-4-{[(2-methylphenyl)carbam...)
Affinity DataKi:  2nMAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613687(CHEMBL5285503)
Affinity DataKi:  2nMAssay Description:Inhibition of wild type human EGFR assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583333(CHEMBL5082573)
Affinity DataKi:  2nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583333(CHEMBL5082573)
Affinity DataKi:  2nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17177((3S)-3-(4-{[3-(3-chloro-4-{[(2-methylphenyl)carbam...)
Affinity DataKi:  2nMAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613698(CHEMBL5282384)
Affinity DataKi:  2nMAssay Description:Inhibition of human EGFR del (746 to 750) mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613698(CHEMBL5282384)
Affinity DataKi:  2nMAssay Description:Inhibition of human EGFR T790M/del (746 to 750 residues) mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 peptide as subs...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613685(CHEMBL5273791)
Affinity DataKi:  2.10nMAssay Description:Inhibition of human EGFR T790M/L858R double mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as peptide substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583338(CHEMBL5088939)
Affinity DataKi:  2.10nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50583346(CHEMBL5078234)
Affinity DataKi:  2.20nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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