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Target
Serine/threonine-protein kinase B-raf
Ligand
BDBM50026210
Substrate
n/a
Meas. Tech.
ChEMBL_685663 (CHEMBL1285565)
IC50
<0.320000±n/a nM
Citation
 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Indazolylpyrazolopyrimidine as highly potent B-Raf inhibitors with in vivo activity. J Med Chem 53:7874-8 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase B-raf
Synonyms:
B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
84446.00
Organism:
Homo sapiens (Human)
Description:
P15056
Residue:
766
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
  
Inhibitor
Name:
BDBM50026210
Synonyms:
CHEMBL1276196
Type:
Small organic molecule
Emp. Form.:
C33H28F2N8
Mol. Mass.:
574.6258
SMILES:
[H][C@]12CN(c3cc(F)c(c(F)c3)-c3ccnc4c(c(nn34)-c3ccncc3)-c3cccc4[nH]ncc34)[C@]([H])(CN1C1CCC1)C2 |r,wU:36.42,1.0,(4.86,-17.8,;3.77,-18.9,;3.78,-20.44,;2.44,-21.22,;2.45,-22.75,;1.12,-23.53,;1.13,-25.07,;-.2,-25.85,;2.46,-25.83,;3.8,-25.06,;5.13,-25.82,;3.79,-23.52,;2.47,-27.37,;1.14,-28.14,;1.14,-29.68,;2.47,-30.45,;3.81,-29.68,;5.28,-30.16,;6.19,-28.9,;5.28,-27.65,;3.81,-28.13,;7.73,-28.9,;8.5,-30.24,;10.04,-30.24,;10.81,-28.9,;10.03,-27.56,;8.5,-27.57,;5.76,-31.62,;7.26,-31.94,;7.74,-33.4,;6.71,-34.55,;5.2,-34.23,;3.95,-35.13,;2.71,-34.22,;3.2,-32.76,;4.73,-32.77,;1.11,-20.46,;-.44,-20.45,;1.1,-18.92,;2.43,-18.13,;2.43,-16.59,;3.51,-15.5,;2.42,-14.42,;1.33,-15.51,;2.19,-19.36,)|
Structure:
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