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Target
Serine/threonine-protein kinase B-raf
Ligand
BDBM50026209
Substrate
n/a
Meas. Tech.
ChEMBL_685663 (CHEMBL1285565)
IC50
<0.320000±n/a nM
Citation
 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Indazolylpyrazolopyrimidine as highly potent B-Raf inhibitors with in vivo activity. J Med Chem 53:7874-8 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase B-raf
Synonyms:
B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
84446.00
Organism:
Homo sapiens (Human)
Description:
P15056
Residue:
766
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
  
Inhibitor
Name:
BDBM50026209
Synonyms:
CHEMBL1276171
Type:
Small organic molecule
Emp. Form.:
C30H25BrN8
Mol. Mass.:
577.477
SMILES:
[H][C@]12CN(c3ccc(c(Br)c3)-c3ccnc4c(c(nn34)-c3ccncc3)-c3cccc4[nH]ncc34)[C@]([H])(CN1C)C2 |r,wU:35.41,1.0,(-8.28,-15.09,;-9.36,-16.19,;-9.36,-17.73,;-10.69,-18.5,;-10.68,-20.03,;-9.35,-20.8,;-9.34,-22.34,;-10.68,-23.12,;-12.01,-22.36,;-13.34,-23.13,;-12.03,-20.82,;-10.67,-24.65,;-12.01,-25.42,;-12.01,-26.97,;-10.67,-27.74,;-9.33,-26.97,;-7.86,-27.45,;-6.94,-26.19,;-7.86,-24.94,;-9.33,-25.42,;-5.41,-26.19,;-4.64,-27.53,;-3.1,-27.53,;-2.33,-26.19,;-3.1,-24.85,;-4.64,-24.86,;-7.38,-28.91,;-5.88,-29.23,;-5.4,-30.69,;-6.43,-31.84,;-7.94,-31.52,;-9.19,-32.42,;-10.42,-31.51,;-9.94,-30.05,;-8.41,-30.06,;-12.04,-17.74,;-13.58,-17.74,;-12.05,-16.21,;-10.7,-15.42,;-10.71,-13.88,;-10.94,-16.64,)|
Structure:
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