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Target
Serine/threonine-protein kinase B-raf
Ligand
BDBM50330907
Substrate
n/a
Meas. Tech.
ChEMBL_685663 (CHEMBL1285565)
IC50
2.3±n/a nM
Citation
 Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Indazolylpyrazolopyrimidine as highly potent B-Raf inhibitors with in vivo activity. J Med Chem 53:7874-8 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase B-raf
Synonyms:
B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
84446.00
Organism:
Homo sapiens (Human)
Description:
P15056
Residue:
766
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
  
Inhibitor
Name:
BDBM50330907
Synonyms:
7-(4-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-ylmethyl)phenyl)-3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine | CHEMBL1276191
Type:
Small organic molecule
Emp. Form.:
C30H26N8
Mol. Mass.:
498.581
SMILES:
C(N1C[C@@H]2C[C@@H]1CN2)c1ccc(cc1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 |r,wU:3.3,wD:5.4,(3.49,-2.92,;4.83,-2.15,;6.16,-2.93,;7.49,-2.16,;6.31,-1.02,;4.82,-.62,;6.15,.15,;7.71,-.52,;3.5,-4.46,;4.84,-5.23,;4.84,-6.77,;3.5,-7.54,;2.18,-6.79,;2.16,-5.24,;3.52,-9.08,;2.19,-9.85,;2.18,-11.4,;3.52,-12.17,;4.85,-11.39,;6.33,-11.87,;7.24,-10.61,;6.33,-9.37,;4.85,-9.84,;8.77,-10.62,;9.54,-11.95,;11.08,-11.95,;11.85,-10.62,;11.08,-9.27,;9.53,-9.28,;6.8,-13.34,;8.3,-13.65,;8.79,-15.11,;7.75,-16.26,;6.24,-15.94,;4.99,-16.84,;3.75,-15.93,;4.23,-14.46,;5.77,-14.47,)|
Structure:
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