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Target
Furin
Ligand
BDBM50333207
Substrate
n/a
Meas. Tech.
ChEMBL_698129 (CHEMBL1646242)
Ki
1460±n/a nM
Citation
 Sielaff, F; Than, ME; Bevec, D; Lindberg, I; Steinmetzer, T New furin inhibitors based on weakly basic amidinohydrazones. Bioorg Med Chem Lett 21:836-40 (2011) [PubMed]  Article 
Target
Name:
Furin
Synonyms:
FUR | FURIN | FURIN_HUMAN | Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA | PACE | PCSK3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
86676.01
Organism:
Human
Description:
P09958
Residue:
794
Sequence:
MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGLSCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL
  
Inhibitor
Name:
BDBM50333207
Synonyms:
CHEMBL1645026 | N-(3-(-1-(2-carbamimidoylhydrazono)ethyl)-5-(-1-(2-carbamimidoylhydrazono)ethyl)phenyl)-2-(3-(-1-(2-carbamimidoylhydrazono)ethyl)phenoxy)acetamide
Type:
Small organic molecule
Emp. Form.:
C23H31N13O2
Mol. Mass.:
521.5781
SMILES:
[#6]-[#6](=[#7]\[#7]=[#6](\[#7])-[#7])-c1cccc(-[#8]-[#6]-[#6](=O)-[#7]-c2cc(cc(c2)-[#6](-[#6])=[#7]\[#7]=[#6](\[#7])-[#7])-[#6](-[#6])=[#7]\[#7]=[#6](\[#7])-[#7])c1 |w:2.2,32.33,25.26|
Structure:
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