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Target
Transcription factor p65
Ligand
BDBM50335582
Substrate
n/a
Meas. Tech.
ChEMBL_714888 (CHEMBL1663834)
IC50
>20000±n/a nM
Citation
 Pan, L; Kardono, LB; Riswan, S; Chai, H; Carcache de Blanco, EJ; Pannell, CM; Soejarto, DD; McCloud, TG; Newman, DJ; Kinghorn, AD Isolation and characterization of minor analogues of silvestrol and other constituents from a large-scale re-collection of Aglaia foveolata. J Nat Prod 73:1873-8 (2010) [PubMed]  Article 
Target
Name:
Transcription factor p65
Synonyms:
NFKB3 | Nuclear factor NF-kappa-B | Nuclear factor NF-kappa-B p65 subunit | RELA | TF65_HUMAN | v-rel reticuloendotheliosis viral oncogene homolog A isoform 1
Type:
Enzyme
Mol. Mass.:
60211.92
Organism:
Homo sapiens (Human)
Description:
Q04206
Residue:
551
Sequence:
MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS
  
Inhibitor
Name:
BDBM50335582
Synonyms:
4,6-Diene-1beta,15-dihydroxyeudesma-3-one | CHEMBL1651035
Type:
Small organic molecule
Emp. Form.:
C15H22O3
Mol. Mass.:
250.3334
SMILES:
CC(C)C1=CC2=C(CO)C(=O)C[C@@H](O)[C@]2(C)CC1 |r,c:5,t:3|
Structure:
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