Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50335732
Substrate
n/a
Meas. Tech.
ChEMBL_715074 (CHEMBL1664180)
Ki
11.3±n/a nM
Citation
 Yaziji, V; Rodríguez, D; Gutiérrez-de-Terán, H; Coelho, A; Caamaño, O; García-Mera, X; Brea, J; Loza, MI; Cadavid, MI; Sotelo, E Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem 54:457-71 (2011) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50335732
Synonyms:
CHEMBL1650377 | N-2,6-bis2,4-dimethoxyphenyl)pyrimidin-4-yl)propionamide
Type:
Small organic molecule
Emp. Form.:
C23H25N3O5
Mol. Mass.:
423.4617
SMILES:
CCC(=O)Nc1cc(nc(n1)-c1ccc(OC)cc1OC)-c1ccc(OC)cc1OC
Structure:
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