Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50335747
Substrate
n/a
Meas. Tech.
ChEMBL_715074 (CHEMBL1664180)
Ki
15.9±n/a nM
Citation
 Yaziji, V; Rodríguez, D; Gutiérrez-de-Terán, H; Coelho, A; Caamaño, O; García-Mera, X; Brea, J; Loza, MI; Cadavid, MI; Sotelo, E Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem 54:457-71 (2011) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50335747
Synonyms:
CHEMBL1650399 | N-(2,6-bis(2,4-dimethoxyphenyl)pyrimidin-4-yl)isobutyramide
Type:
Small organic molecule
Emp. Form.:
C24H27N3O5
Mol. Mass.:
437.4883
SMILES:
COc1ccc(c(OC)c1)-c1cc(NC(=O)C(C)C)nc(n1)-c1ccc(OC)cc1OC
Structure:
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