Reaction Details Report a problem with these data
Target
L-lactate dehydrogenase A chain
Ligand
BDBM50339607
Substrate
n/a
Meas. Tech.
ChEMBL_734830 (CHEMBL1692980)
Ki
4700±n/a nM
Citation
 Granchi, C; Roy, S; Giacomelli, C; Macchia, M; Tuccinardi, T; Martinelli, A; Lanza, M; Betti, L; Giannaccini, G; Lucacchini, A; Funel, N; León, LG; Giovannetti, E; Peters, GJ; Palchaudhuri, R; Calvaresi, EC; Hergenrother, PJ; Minutolo, F Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells. J Med Chem 54:1599-612 (2011) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase A chain
Synonyms:
Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59
Type:
Protein
Mol. Mass.:
36694.85
Organism:
Homo sapiens (Human)
Description:
P00338::PDB Code: 4ajp
Residue:
332
Sequence:
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF
  
Inhibitor
Name:
BDBM50339607
Synonyms:
1-Hydroxy-6-phenyl-4-trifluoromethyl-1H-indole-2-carboxylic Acid | CHEMBL1688790 | LDHA Inhibitor, 4
Type:
Small organic molecule
Emp. Form.:
C16H10F3NO3
Mol. Mass.:
321.2507
SMILES:
OC(=O)c1cc2c(cc(cc2n1O)-c1ccccc1)C(F)(F)F
Structure:
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