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Target
Cannabinoid receptor 2
Ligand
BDBM50341919
Substrate
n/a
Meas. Tech.
ChEMBL_743422 (CHEMBL1767776)
IC50
4.9±n/a nM
Citation
 Manley, PJ; Zartman, A; Paone, DV; Burgey, CS; Henze, DA; Della Penna, K; Desai, R; Leitl, MD; Lemaire, W; White, RB; Yeh, S; Urban, MO; Kane, SA; Hartman, GD; Bilodeau, MT; Trotter, BW Decahydroquinoline amides as highly selective CB2 agonists: role of selectivity on in vivo efficacy in a rodent model of analgesia. Bioorg Med Chem Lett 21:2359-64 (2011) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50341919
Synonyms:
((4aR,8aS)-4-hydroxy-4-phenyloctahydroquinolin-1(2H)-yl)(1H-indazol-4-yl)methanone | ((4aR,8aS)-4-hydroxy-4-phenyloctahydroquinolin-1(2H)-yl)(pyridin-2-yl)methanone | CHEMBL1765278
Type:
Small organic molecule
Emp. Form.:
C23H25N3O2
Mol. Mass.:
375.4635
SMILES:
OC1(CCN([C@H]2CCCC[C@@H]12)C(=O)c1cccc2[nH]ncc12)c1ccccc1 |r|
Structure:
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