Reaction Details Report a problem with these data
Target
Solute carrier family 5 member 4
Ligand
BDBM50342885
Substrate
n/a
Meas. Tech.
ChEMBL_745217 (CHEMBL1772493)
IC50
0.877±n/a nM
Citation
 Mascitti, V; Maurer, TS; Robinson, RP; Bian, J; Boustany-Kari, CM; Brandt, T; Collman, BM; Kalgutkar, AS; Klenotic, MK; Leininger, MT; Lowe, A; Maguire, RJ; Masterson, VM; Miao, Z; Mukaiyama, E; Patel, JD; Pettersen, JC; Préville, C; Samas, B; She, L; Sobol, Z; Steppan, CM; Stevens, BD; Thuma, BA; Tugnait, M; Zeng, D; Zhu, T Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors. J Med Chem 54:2952-60 (2011) [PubMed]  Article 
Target
Name:
Solute carrier family 5 member 4
Synonyms:
Na(+)/glucose cotransporter 3 | Sodium/glucose cotransporter 3 | Solute carrier family 5 member 4 | SC5A4_HUMAN | SLC5A4 | SAAT1 | SGLT3 | Low affinity sodium-glucose cotransporter
Type:
PROTEIN
Mol. Mass.:
72452.26
Organism:
Human
Description:
ChEMBL_764617
Residue:
659
Sequence:
MASTVSPSTIAETPEPPPLSDHIRNAADISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLTISASCYTPRADSFHIFRDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKHCGVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYGTGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIDAEEKSQEETDDGVEEDYPEKSRGCLKKAYDLFCGLQKGPKLTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA
  
Inhibitor
Name:
BDBM50342885
Synonyms:
(1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-1-(hydroxymethyl)-6,8-dioxa-bicyclo[3.2.1]octane-2,3,4-triol | CHEMBL1770248 | 5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1-hydroxymethyl-6,8-dioxabicyclo(3.2.1)octane-2,3,4-triol | ertugliflozin | PF-04971729 | Steglatro
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: