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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50344220
Substrate
n/a
Meas. Tech.
ChEMBL_747911 (CHEMBL1781230)
EC50
13900±n/a nM
Citation
 Sakuma, S; Endo, T; Kanda, T; Nakamura, H; Yamasaki, S; Yamakawa, T Biological evaluation of novel benzisoxazole derivatives as PPARd agonists. Bioorg Med Chem 19:3255-64 (2011) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50344220
Synonyms:
2-[3-[2-[2-(2-Chlorophenyl)-5-propyl-4-oxazolyl]ethyl]-1,2-benzisoxazol-6-yloxy]-2-methylpropionic acid | CHEMBL1778830
Type:
Small organic molecule
Emp. Form.:
C25H25ClN2O5
Mol. Mass.:
468.929
SMILES:
CCCc1oc(nc1CCc1noc2cc(OC(C)(C)C(O)=O)ccc12)-c1ccccc1Cl
Structure:
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