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Target
Histamine H3 receptor
Ligand
BDBM50346208
Substrate
n/a
Meas. Tech.
ChEMBL_749355 (CHEMBL1785145)
Ki
5±n/a nM
Citation
 Swanson, DM; Shah, CR; Lord, B; Morton, K; Dvorak, LK; Mazur, C; Apodaca, R; Xiao, W; Boggs, JD; Feinstein, M; Wilson, SJ; Barbier, AJ; Bonaventure, P; Lovenberg, TW; Carruthers, NI Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists. Eur J Med Chem 44:4413-25 (2009) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50346208
Synonyms:
(1-isopropylpiperidin-4-yl)(4-(piperidin-1-ylmethyl)phenyl)methanone | CHEMBL1783889
Type:
Small organic molecule
Emp. Form.:
C20H31N3O
Mol. Mass.:
329.4796
SMILES:
CC(C)N1CCN(CC1)C(=O)c1ccc(CN2CCCCC2)cc1
Structure:
Search PDB for entries with ligand similarity: