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Target
Polyunsaturated fatty acid lipoxygenase ALOX15
Ligand
BDBM50350396
Substrate
n/a
Meas. Tech.
ChEMBL_761404 (CHEMBL1817034)
IC50
>150000±n/a nM
Citation
 Kenyon, V; Rai, G; Jadhav, A; Schultz, L; Armstrong, M; Jameson, JB; Perry, S; Joshi, N; Bougie, JM; Leister, W; Taylor-Fishwick, DA; Nadler, JL; Holinstat, M; Simeonov, A; Maloney, DJ; Holman, TR Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. J Med Chem 54:5485-97 (2011) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX15
Synonyms:
Alox12l | Alox15 | Arachidonate 15-lipoxygenase | LOX15_MOUSE
Type:
PROTEIN
Mol. Mass.:
75439.28
Organism:
Mus musculus
Description:
ChEMBL_761404
Residue:
663
Sequence:
MGVYRIRVSTGDSVYAGSNNEVYLWLIGQHGEASLGKLFRPCRNSEAEFKVDVSEYLGPLLFVRVQKWHYLKEDAWFCNWISVKGPGDQGSEYTFPCYRWVQGTSILNLPEGTGCTVVEDSQGLFRNHREEELEERRSLYRWGNWKDGTILNVAATSISDLPVDQRFREDKRLEFEASQVLGTMDTVINFPKNTVTCWKSLDDFNYVFKSGHTKMAERVRNSWKEDAFFGYQFLNGANPMVLKRSTCLPARLVFPPGMEKLQAQLDEELKKGTLFEADFFLLDGIKANVILCSQQYLAAPLVMLKLQPDGQLLPIAIQLELPKTGSTPPPIFTPLDPPMDWLLAKCWVRSSDLQLHELQAHLLRGHLVAEVFAVATMRCLPSVHPVFKLLVPHLLYTMEINVRARSDLISERGFFDKVMSTGGGGHLDLLKQAGAFLTYSSLCPPDDLAERGLLDIDTCFYAKDALQLWQVMNRYVVGMFDLYYKTDQAVQDDYELQSWCQEITEIGLQGAQDRGFPTSLQSRAQACHFITMCIFTCTAQHSSIHLGQLDWFYWVPNAPCTMRLPPPKTKDATMEKLMATLPNPNQSTLQINVVWLLGRRQAVMVPLGQHSEEHFPNPEAKAVLKKFREELAALDKEIEIRNKSLDIPYEYLRPSLVENSVAI
  
Inhibitor
Name:
BDBM50350396
Synonyms:
CHEMBL1573436
Type:
Small organic molecule
Emp. Form.:
C16H13BrN2O2S
Mol. Mass.:
377.256
SMILES:
CC(=O)NC(c1cccs1)c1cc(Br)c2cccnc2c1O
Structure:
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