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Target
Vesicular acetylcholine transporter
Ligand
BDBM50351980
Substrate
n/a
Meas. Tech.
ChEMBL_765941 (CHEMBL1827957)
Ki
1970±n/a nM
Citation
 Wang, W; Cui, J; Lu, X; Padakanti, PK; Xu, J; Parsons, SM; Luedtke, RR; Rath, NP; Tu, Z Synthesis and in vitro biological evaluation of carbonyl group-containing analogues fors1 receptors. J Med Chem 54:5362-72 (2011) [PubMed]  Article 
Target
Name:
Vesicular acetylcholine transporter
Synonyms:
SLC18A3 | Solute carrier family 18 member 3 | VACHT | VACHT_HUMAN
Type:
PROTEIN
Mol. Mass.:
56900.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507628
Residue:
532
Sequence:
MESAEPAGQARAAATKLSEAVGAALQEPRRQRRLVLVIVCVALLLDNMLYMVIVPIVPDYIAHMRGGGEGPTRTPEVWEPTLPLPTPANASAYTANTSASPTAAWPAGSALRPRYPTESEDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVLFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMAWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGASSCIVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRSERDVLLDEPPQGLYDAVRLRERPVSGQDGEPRSPPGPFDACEDDYNYYYTRS
  
Inhibitor
Name:
BDBM50351980
Synonyms:
CHEMBL1822402
Type:
Small organic molecule
Emp. Form.:
C25H31FN2O3
Mol. Mass.:
426.5236
SMILES:
COc1ccc(CN2CC[C@H](O)[C@H](C2)N2CCC(CC2)C(=O)c2ccc(F)cc2)cc1 |r|
Structure:
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