Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50351968
Substrate
n/a
Meas. Tech.
ChEMBL_765939 (CHEMBL1827955)
Ki
2.5±n/a nM
Citation
 Wang, W; Cui, J; Lu, X; Padakanti, PK; Xu, J; Parsons, SM; Luedtke, RR; Rath, NP; Tu, Z Synthesis and in vitro biological evaluation of carbonyl group-containing analogues fors1 receptors. J Med Chem 54:5362-72 (2011) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50351968
Synonyms:
CHEMBL1822390
Type:
Small organic molecule
Emp. Form.:
C25H31FN2O3
Mol. Mass.:
426.5236
SMILES:
COc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2ccc(F)cc2)C[C@@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: