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Target
Cytochrome P450 2D6
Ligand
BDBM50352206
Substrate
n/a
Meas. Tech.
ChEMBL_767449 (CHEMBL1825561)
IC50
>10000±n/a nM
Citation
 Zhang, L; Fan, J; Chong, JH; Cesena, A; Tam, BY; Gilson, C; Boykin, C; Wang, D; Aivazian, D; Marcotte, D; Xiao, G; Le Brazidec, JY; Piao, J; Lundgren, K; Hong, K; Vu, K; Nguyen, K; Gan, LS; Silvian, L; Ling, L; Teng, M; Reff, M; Takeda, N; Timple, N; Wang, Q; Morena, R; Khan, S; Zhao, S; Li, T; Lee, WC; Taveras, AG; Chao, J Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I). Bioorg Med Chem Lett 21:5633-7 (2011) [PubMed]  Article 
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
  
Inhibitor
Name:
BDBM50352206
Synonyms:
CHEMBL1825089
Type:
Small organic molecule
Emp. Form.:
C25H35N7O3S
Mol. Mass.:
513.655
SMILES:
CS(=O)(=O)N(CCN1CCOCC1)c1ccc(Nc2ncc3cnn(C4CCCCCC4)c3n2)cc1
Structure:
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