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Target
Aurora kinase C
Ligand
BDBM50352312
Substrate
n/a
Meas. Tech.
ChEMBL_766654 (CHEMBL1827220)
Kd
5±n/a nM
Citation
 Abraham, S; Hadd, MJ; Tran, L; Vickers, T; Sindac, J; Milanov, ZV; Holladay, MW; Bhagwat, SS; Hua, H; Ford Pulido, JM; Cramer, MD; Gitnick, D; James, J; Dao, A; Belli, B; Armstrong, RC; Treiber, DK; Liu, G Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors. Bioorg Med Chem Lett 21:5296-300 (2011) [PubMed]  Article 
Target
Name:
Aurora kinase C
Synonyms:
AIE2 | AIK3 | AIRK3 | ARK3 | AURKC | AURKC_HUMAN | Aurora Kinase C (Aurora-C) | Aurora kinase C | Aurora kinase C (AURKC) | Aurora-C | Aurora-C/INCENP | Aurora/Ipl1-related kinase 3 | Aurora/Ipl1/Eg2 protein 2 | STK13 | Serine/threonine-protein kinase 13 | Serine/threonine-protein kinase Aurora-C
Type:
Enzyme
Mol. Mass.:
35602.43
Organism:
Homo sapiens (Human)
Description:
Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system.
Residue:
309
Sequence:
MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
  
Inhibitor
Name:
BDBM50352312
Synonyms:
CHEMBL1822494
Type:
Small organic molecule
Emp. Form.:
C20H22N8OS
Mol. Mass.:
422.507
SMILES:
CN(C)CC(=O)Nc1ccc(Sc2nc(Nc3cc(C)[nH]n3)c3cccn3n2)cc1
Structure:
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