Reaction Details Report a problem with these data
Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50356343
Substrate
n/a
Meas. Tech.
ChEMBL_775374 (CHEMBL1912903)
IC50
134±n/a nM
Citation
Ye, XY; Chen, SY; Nayeem, A; Golla, R; Seethala, R; Wang, M; Harper, T; Sleczka, BG; Li, YX; He, B; Kirby, M; Gordon, DA; Robl, JA Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1). Bioorg Med Chem Lett 21:6699-704 (2011) [PubMed] Article
More Info.:
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1
Type:
Enzyme
Mol. Mass.:
32369.70
Organism:
Mus musculus (mouse)
Description:
P50172
Residue:
292
Sequence:
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
Inhibitor
Name:
BDBM50356343
Synonyms:
CHEMBL1911406
Type:
Small organic molecule
Emp. Form.:
C19H24O3
Mol. Mass.:
300.3921
SMILES:
COc1ccc(cc1)C1(CC(O)=O)C2CC3CC(C2)CC1C3 |TLB:21:20:18:14.15.16,9:8:14.21.15:19.17.18,THB:21:15:8.20.19:18,16:15:8:19.17.18,16:17:8:14.21.15,9:8:18:14.15.16,5:8:14.21.15:19.17.18,(20.62,-30.43,;22.16,-30.39,;22.9,-29.04,;22.1,-27.72,;22.84,-26.37,;24.38,-26.35,;25.18,-27.65,;24.45,-29,;25.12,-25,;23.78,-24.22,;23.79,-22.68,;22.45,-21.9,;25.12,-21.91,;26.32,-23.72,;27.65,-24.21,;29.04,-23.86,;29.06,-22.33,;27.66,-21.75,;26.31,-22.23,;26.62,-22.99,;26.62,-24.58,;28.03,-25.14,)|