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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50356340
Substrate
n/a
Meas. Tech.
ChEMBL_775369 (CHEMBL1912854)
IC50
4±n/a nM
Citation
 Ye, XY; Chen, SY; Nayeem, A; Golla, R; Seethala, R; Wang, M; Harper, T; Sleczka, BG; Li, YX; He, B; Kirby, M; Gordon, DA; Robl, JA Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1). Bioorg Med Chem Lett 21:6699-704 (2011) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50356340
Synonyms:
CHEMBL1911409
Type:
Small organic molecule
Emp. Form.:
C18H21ClO2
Mol. Mass.:
304.811
SMILES:
OC(=O)CC1(C2CC3CC(C2)CC1C3)c1cccc(Cl)c1 |TLB:13:12:10:6.7.8,3:4:6.13.7:11.9.10,THB:13:7:4.12.11:10,8:7:4:11.9.10,8:9:4:6.13.7,3:4:10:6.7.8,14:4:6.13.7:11.9.10,(24.11,-35.98,;25.44,-36.76,;26.78,-35.99,;25.44,-38.3,;26.78,-39.08,;27.97,-37.8,;29.3,-38.29,;30.7,-37.94,;30.71,-36.41,;29.31,-35.83,;27.97,-36.31,;28.27,-37.07,;28.28,-38.66,;29.69,-39.22,;26.03,-40.43,;26.84,-41.74,;26.1,-43.09,;24.55,-43.12,;23.75,-41.8,;22.21,-41.84,;24.5,-40.45,)|
Structure:
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