Reaction Details Report a problem with these data
Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50356347
Substrate
n/a
Meas. Tech.
ChEMBL_775369 (CHEMBL1912854)
IC50
425±n/a nM
Citation
Ye, XY; Chen, SY; Nayeem, A; Golla, R; Seethala, R; Wang, M; Harper, T; Sleczka, BG; Li, YX; He, B; Kirby, M; Gordon, DA; Robl, JA Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1). Bioorg Med Chem Lett 21:6699-704 (2011) [PubMed] Article
More Info.:
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
Inhibitor
Name:
BDBM50356347
Synonyms:
CHEMBL1911402
Type:
Small organic molecule
Emp. Form.:
C18H21FO3
Mol. Mass.:
304.3559
SMILES:
OC(=O)CC1(C2CC3CC1CC(O)(C3)C2)c1ccc(F)cc1 |TLB:14:11:4.5.6:8,3:4:10.14.11:6.7.8,3:4:8:10.11.13,THB:14:5:8:10.11.13,12:11:4:6.7.8,12:11:4.5.6:8,13:11:4:6.7.8,13:7:4:10.14.11,15:4:10.14.11:6.7.8,(7.01,-8.14,;8.34,-8.91,;9.67,-8.14,;8.33,-10.45,;9.67,-11.23,;11.18,-10.81,;11.17,-9.22,;12.21,-7.99,;10.86,-8.47,;10.87,-9.95,;12.2,-10.44,;13.6,-10.1,;15.14,-10.04,;13.61,-8.57,;12.58,-11.37,;8.93,-12.58,;7.39,-12.61,;6.65,-13.96,;7.45,-15.28,;6.71,-16.63,;9,-15.24,;9.73,-13.89,)|